Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 2/20 | 0.65 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.65 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.65 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.65 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | THRB | P10828 | 1/20 | 0.65 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.65 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.65 |
| ▸ | BLM | P54132 | 1/20 | 0.62 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | THPO | P40225 | 1/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL10920212 | 0.98 | BLM (0.66) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL5203140 | 0.83 | CHRM2 (0.65) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL336164 | 0.83 | CHRM2 (0.65) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Hydrochloric Acid SCHEMBL11584066 | 0.82 | CHRM2 (0.62) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Bromide SCHEMBL9568894 | 0.82 | BLM (0.66) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Hydrochloric Acid SCHEMBL2197726 | 0.82 | CHRM2 (0.62) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Ammonia Solution, Strong SCHEMBL30785800 | 0.82 | CHRM2 (0.62) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Hydrochloric Acid SCHEMBL1897878 | 0.80 | CHRM2 (0.61) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL12798275 | 0.79 | CHRM2 (0.59) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL15600774 | 0.79 | CHRM2 (0.64) | CHRM2CHRM4CHRM5CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0288394-A2 | 1,2,5,6-Tetrahydropyridines, process for their preparation, their use as medicines and compositions containing them | ROUSSEL-UCLAF (FR) | 1988-10-26 | — | — | EP | claimed |
| US-4710508-A | ANALGESICS | WARNER-LAMBERT COMPANY (US) | 1987-12-01 | — | — | US | claimed |
| EP-0091565-B1 | PROCESS FOR THE MANUFACTURE OF ISOQUINOLINE DIONES | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1986-04-23 | — | — | EP | claimed |
| US-4495354-A | Process for bicyclic diketones | HOFFMANN-LA ROCHE INC. (US) | 1985-01-22 | — | — | US | claimed |
| EP-0091565-A1 | Process for the manufacture of isoquinoline diones | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1983-10-19 | — | — | EP | claimed |
| CN-110505884-B | Anti-cancer combination therapy | 勃林格殷格翰国际有限公司 | 2022-08-12 | — | — | CN | disclosed |
| US-7160900-B2 | Tetrahydropyridino or piperidino heterocyclic derivatives | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2007-01-09 | — | — | US | disclosed |
| EP-0537993-A1 | Nicotinic activity of a series of arecolones and isoarecolones | ELI LILLY AND COMPANY (US) | 1993-04-21 | — | — | EP | disclosed |
| US-4710508-A | ANALGESICS | WARNER-LAMBERT COMPANY (US) | 1987-12-01 | — | — | US | disclosed |
| EP-0091565-B1 | PROCESS FOR THE MANUFACTURE OF ISOQUINOLINE DIONES | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1986-04-23 | — | — | EP | disclosed |
| US-4495354-A | Process for bicyclic diketones | HOFFMANN-LA ROCHE INC. (US) | 1985-01-22 | — | — | US | disclosed |
| EP-0091565-A1 | Process for the manufacture of isoquinoline diones | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1983-10-19 | — | — | EP | disclosed |