Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 13/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 7/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.54 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12309221 | 0.81 | KDM4E (0.58) | KDM4EALDH1A1PKMHPGDSMN1; SMN2 | |
| SCHEMBL8352732 | 0.81 | KDM4E (0.59) | KDM4EALDH1A1PKMHPGDSMN1; SMN2 | |
| SCHEMBL9597409 | 0.81 | KDM4E (0.58) | KDM4EALDH1A1PKMHPGDSMN1; SMN2 | |
| SCHEMBL2813856 | 0.81 | KDM4E (0.58) | KDM4EALDH1A1PKMHPGDSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL260050 | 0.80 | KDM4E (0.56) | KDM4EALDH1A1PKMHPGDSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL17184524 | 0.80 | KDM4E (0.56) | KDM4EALDH1A1PKMHPGDSMN1; SMN2 | |
| SCHEMBL9946224 | 0.79 | KDM4E (0.56) | KDM4EALDH1A1PKMHPGDSMN1; SMN2 | |
| SCHEMBL538320 | 0.79 | KDM4E (0.56) | KDM4EALDH1A1PKMHPGDSMN1; SMN2 | |
| SCHEMBL1271461 | 0.78 | KDM4E (0.61) | KDM4EALDH1A1PKMHPGDSMN1; SMN2 | |
| SCHEMBL1271462 | 0.78 | KDM4E (0.65) | KDM4EALDH1A1PKMHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5270322-A | Imidazo[1,2-a]pyridines, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1993-12-14 | — | — | US | disclosed |
| EP-0555825-A1 | Imidazo(1,2-a)pyridines as angiotensin-II-antagonists | Dr. Karl Thomae GmbH (DE) | 1993-08-18 | — | — | EP | disclosed |