Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 4/20 | 0.60 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29580533 | 0.86 | KMT2A (0.69) | KMT2ASMN1; SMN2MEN1EPHX2KDM4E | |
| SCHEMBL31658991 | 0.85 | KMT2A (0.83) | KMT2ASMN1; SMN2MEN1EPHX2ALOX15 | |
| SCHEMBL9341104 | 0.85 | KMT2A (0.83) | KMT2ASMN1; SMN2MEN1EPHX2ALOX15 | |
| SCHEMBL1503134 | 0.83 | KMT2A (0.65) | KMT2ASMN1; SMN2MEN1EPHX2HTT | |
| SCHEMBL28244458 | 0.83 | KMT2A (0.65) | KMT2ASMN1; SMN2MEN1EPHX2HTT | |
| SCHEMBL4134594 | 0.82 | KMT2A (0.59) | KMT2ASMN1; SMN2MEN1EPHX2HTT | |
| SCHEMBL2516053 | 0.81 | KDM4E (0.69) | KMT2ASMN1; SMN2MEN1EPHX2HTT | |
| SCHEMBL16215618 | 0.81 | KMT2A (0.63) | KMT2ASMN1; SMN2MEN1EPHX2HTT | |
| SCHEMBL8516755 | 0.81 | SMN1; SMN2 (0.90) | KMT2ASMN1; SMN2MEN1EPHX2ALOX15 | |
| SCHEMBL509641 | 0.81 | KMT2A (0.63) | KMT2ASMN1; SMN2MEN1EPHX2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2454250-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | Gilead Sciences, Inc. (US) | 2012-05-23 | — | — | EP | claimed |
| WO-2011008709-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2011-01-20 | — | — | WO | claimed |