Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 3/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.38 |
| ▸ | HTR3B | O95264 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.38 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21540373 | 0.85 | GRM2 (0.44) | GRM2PDE10AHTR3EHTR3BHTR3A | |
| SCHEMBL9597780 | 0.84 | GRM2 (0.44) | GRM2HDAC6PDE10AHTR3EHTR3B | |
| SCHEMBL6491453 | 0.81 | GRM2 (0.46) | GRM2PDE10AHTR3EHTR3BHTR3A | |
| SCHEMBL10313043 | 0.80 | GRM2 (0.45) | GRM2HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL4762190 | 0.80 | GRM2 (0.45) | GRM2HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL6647059 | 0.80 | GRM2 (0.48) | GRM2HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL8279970 | 0.77 | GRM2 (0.44) | GRM2HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL12776003 | 0.77 | GRM2 (0.46) | GRM2HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL18306496 | 0.77 | GRM2 (0.44) | GRM2MAPTLMNAPKM | |
| SCHEMBL8110814 | 0.75 | NPC1 (0.44) | GRM2PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5270322-A | Imidazo[1,2-a]pyridines, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1993-12-14 | — | — | US | disclosed |
| EP-0555825-A1 | Imidazo(1,2-a)pyridines as angiotensin-II-antagonists | Dr. Karl Thomae GmbH (DE) | 1993-08-18 | — | — | EP | disclosed |