Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | PAK4 | O96013 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | MET | P08581 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | PRKACA | P17612 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | LTK | P29376 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9597339 | 0.87 | MCHR1 (0.50) | CHEK1AURKADAPK3JAK2PRKD3 | |
| SCHEMBL10066171 | 0.86 | CHEK1 (0.45) | CHEK1AURKADAPK3JAK2PRKD3 | |
| SCHEMBL13384211 | 0.86 | ABL1 (0.45) | CHEK1AURKADAPK3JAK2PRKD3 | |
| SCHEMBL5401674 | 0.80 | KDM4E (0.42) | CHEK1AURKADAPK3JAK2PRKD3 | |
| SCHEMBL30845741 | 0.78 | EGLN1 (0.52) | CHEK1AURKADAPK3JAK2PRKD3 | |
| SCHEMBL29651927 | 0.78 | KDM4E (0.43) | CHEK1AURKADAPK3JAK2PRKD3 | |
| SCHEMBL10053505 | 0.77 | MCHR1 (0.48) | CHEK1AURKADAPK3JAK2PRKD3 | |
| SCHEMBL17336347 | 0.76 | F7 (0.43) | FYNRETGRK5CCNE1CDK2 | |
| SCHEMBL327269 | 0.75 | PTGS1 (0.54) | CHEK1AURKADAPK3JAK2PRKD3 | |
| SCHEMBL9570490 | 0.74 | NPC1 (0.50) | CDK5KDM4EALDH1A1POLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5270322-A | Imidazo[1,2-a]pyridines, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1993-12-14 | — | — | US | disclosed |
| EP-0555825-A1 | Imidazo(1,2-a)pyridines as angiotensin-II-antagonists | Dr. Karl Thomae GmbH (DE) | 1993-08-18 | — | — | EP | disclosed |