Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.63 |
| ▸ | PPARD | Q03181 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL830528 | 0.79 | TSHR (0.60) | TSHRPPARDTP53TDP1MEN1 | |
| SCHEMBL282472 | 0.78 | TSHR (0.67) | TSHRPPARDTP53TDP1MEN1 | |
| SCHEMBL3313657 | 0.78 | PPARD (0.70) | TSHRPPARDTP53TDP1MEN1 | |
| SCHEMBL5961215 | 0.78 | TSHR (1.00) | TSHRPPARDTP53TDP1MEN1 | |
| SCHEMBL26483 | 0.78 | TSHR (1.00) | TSHRPPARDTP53TDP1MEN1 | |
| SCHEMBL28492909 | 0.75 | TSHR (0.94) | TSHRPPARDTP53TDP1MEN1 | |
| SCHEMBL31574613 | 0.75 | TSHR (0.94) | TSHRPPARDTP53TDP1MEN1 | |
| SCHEMBL29034374 | 0.75 | TSHR (0.94) | TSHRPPARDTP53TDP1MEN1 | |
| SCHEMBL9654507 | 0.75 | TSHR (0.63) | TSHRPPARDTP53TDP1MEN1 | |
| SCHEMBL11745101 | 0.75 | TSHR (0.94) | TSHRPPARDTP53TDP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5270322-A | Imidazo[1,2-a]pyridines, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1993-12-14 | — | — | US | disclosed |
| EP-0555825-A1 | Imidazo(1,2-a)pyridines as angiotensin-II-antagonists | Dr. Karl Thomae GmbH (DE) | 1993-08-18 | — | — | EP | disclosed |