Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dimethylformamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA4 | P22748 | 4/20 | 0.37 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.30 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | LDHA | P00338 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethylformamide SCHEMBL5002230 | 1.00 | TSHR (0.60) | TSHRCA1CA4FAHD1USP2 | |
| Dimethylformamide SCHEMBL28258465 | 0.97 | TSHR (0.56) | TSHRCA1CA4FAHD1 | |
| Dimethylformamide SCHEMBL7257761 | 0.93 | TSHR (0.60) | TSHRCA1CA4FAHD1USP2 | |
| Dimethylformamide SCHEMBL20398853 | 0.93 | TSHR (0.60) | TSHRCA1CA4USP2ALOX15 | |
| Dimethylformamide SCHEMBL6666132 | 0.90 | CA1 (0.56) | TSHRCA1CA4FAHD1 | |
| Dimethylformamide SCHEMBL9574666 | 0.90 | TSHR (0.56) | TSHRCA1CA4FAHD1 | |
| Dimethylformamide SCHEMBL2022284 | 0.84 | TSHR (0.56) | TSHRCA1CA4FAHD1 | |
| Dimethylformamide SCHEMBL11454512 | 0.84 | TSHR (0.56) | TSHRCA1CA4 | |
| Dimethylformamide SCHEMBL10800682 | 0.84 | TSHR (0.56) | TSHRCA1CA4 | |
| Dimethylformamide SCHEMBL28095581 | 0.84 | TSHR (0.56) | TSHRCA1CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0251795-B1 | NEW COMPOUNDS AND THEIR APPLICATION | Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo (JP) | 1993-01-20 | — | — | EP | disclosed |
| US-4894359-A | BIS(PHENOXYMETHYL)BENZENE DERIVATIVES | KABUSHIKI KAISHA UENO SEIYAKU OYO KENKYUJO (JP) | 1990-01-16 | — | — | US | disclosed |
| US-4855482-A | New compounds and their application | KABUSHIKI KAISHA UENO SEIYAKU OYO KENKYUJO (JP) | 1989-08-08 | — | — | US | disclosed |
| EP-0251795-A2 | New compounds and their application | Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo (JP) | 1988-01-07 | — | — | EP | disclosed |