Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.42 |
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.42 |
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.42 |
| ▸ | CHRM4 known ✓ | P08173 | 1/20 | 0.42 |
| ▸ | CHRM5 known ✓ | P08912 | 1/20 | 0.42 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.42 |
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 3/20 | 0.47 |
| ▸ | AKT2 | P31751 | 3/20 | 0.47 |
| ▸ | AKT3 | Q9Y243 | 3/20 | 0.47 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | PRKCG | P05129 | 1/20 | 0.44 |
| ▸ | PRKCB | P05771 | 1/20 | 0.44 |
| ▸ | PRKCA | P17252 | 1/20 | 0.44 |
| ▸ | PRKCH | P24723 | 1/20 | 0.44 |
| ▸ | PRKCI | P41743 | 1/20 | 0.44 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.44 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL9575784 | 1.00 | AKT1 (0.47) | AKT1AKT2AKT3PIK3R1PIK3CA | |
| Bromide SCHEMBL9575791 | 1.00 | AKT1 (0.47) | AKT1AKT2AKT3PIK3R1PIK3CA | |
| Bromide SCHEMBL10507974 | 0.86 | RAD52 (0.42) | LPAR6LPAR1LPAR4LPAR5LPAR2 | |
| Bromide SCHEMBL9575965 | 0.86 | EPHX1 (0.39) | HSP90AA1RAD52CHRM2ADRA2AADORA3 | |
| Bromide SCHEMBL9575832 | 0.86 | GMNN (0.56) | LMNATSHR | |
| Bromide SCHEMBL9575968 | 0.86 | EPHX1 (0.39) | HSP90AA1RAD52CHRM2ADRA2AADORA3 | |
| Bromide SCHEMBL9575825 | 0.86 | GMNN (0.56) | LMNATSHR | |
| Bromide SCHEMBL9575963 | 0.86 | EPHX1 (0.39) | HSP90AA1RAD52CHRM2ADRA2AADORA3 | |
| Bromide SCHEMBL9575836 | 0.85 | RAD52 (0.41) | HSP90AA1RAD52CHRM2ADRA2AADORA3 | |
| SCHEMBL5610889 | 0.82 | AKT1 (0.62) | AKT1AKT2AKT3PIK3R1PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5187293-A | Blood platelet activating factor inhibitors | HOFFMANN-LA ROCHE INC. (US) | 1993-02-16 | — | — | US | disclosed |
| US-4731373-A | BLOOD PLATELET ACTIVATING FACTOR | HOFFMAN-LA ROCHE INC. (US) | 1988-03-15 | — | — | US | disclosed |