Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GMNN | O75496 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | PTAFR | P25105 | 1/20 | 0.49 |
| ▸ | MTOR | P42345 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | AKT1 | P31749 | 2/20 | 0.37 |
| ▸ | AKT2 | P31751 | 2/20 | 0.37 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL9575817 | 1.00 | GMNN (0.49) | GMNNUSP2LMNAPTAFRMTOR | |
| Bromide SCHEMBL9575872 | 0.91 | GMNN (0.47) | GMNNUSP2LMNAPTAFRMTOR | |
| Bromide SCHEMBL9575865 | 0.91 | GMNN (0.47) | GMNNUSP2LMNAPTAFRMTOR | |
| Hydrochloric Acid SCHEMBL11064109 | 0.85 | GMNN (0.58) | GMNNUSP2LMNAPTAFRMTOR | |
| SCHEMBL9120138 | 0.84 | GMNN (0.62) | GMNNUSP2LMNAPTAFRMTOR | |
| SCHEMBL9120153 | 0.84 | GMNN (0.62) | GMNNUSP2LMNAPTAFRMTOR | |
| Iodide SCHEMBL9117189 | 0.83 | GMNN (0.61) | GMNNUSP2LMNAPTAFRMTOR | |
| Iodide SCHEMBL9117195 | 0.83 | GMNN (0.61) | GMNNUSP2LMNAPTAFRMTOR | |
| Bromide SCHEMBL10815643 | 0.79 | GMNN (0.41) | GMNNUSP2LMNAPTAFRMTOR | |
| Bromide SCHEMBL9575968 | 0.77 | EPHX1 (0.39) | LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5187293-A | Blood platelet activating factor inhibitors | HOFFMANN-LA ROCHE INC. (US) | 1993-02-16 | — | — | US | disclosed |
| US-4731373-A | BLOOD PLATELET ACTIVATING FACTOR | HOFFMAN-LA ROCHE INC. (US) | 1988-03-15 | — | — | US | disclosed |