Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 3/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | TERT | O14746 | 1/20 | 0.34 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.34 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | AHR | P35869 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9585265 | 1.00 | MAP3K14 (0.54) | MAP3K14ADRA2ADRD2DRD3HCRTR2 | |
| SCHEMBL9585257 | 1.00 | MAP3K14 (0.54) | MAP3K14ADRA2ADRD2DRD3HCRTR2 | |
| SCHEMBL16397491 | 0.80 | MAP3K14 (0.75) | MAP3K14ADRA2ADRD2DRD3HCRTR2 | |
| SCHEMBL24997240 | 0.80 | MAP3K14 (0.75) | MAP3K14ADRA2ADRD2DRD3HCRTR2 | |
| SCHEMBL24393413 | 0.80 | MAP3K14 (0.75) | MAP3K14ADRA2ADRD2DRD3HCRTR2 | |
| SCHEMBL1265783 | 0.73 | MAP3K14 (0.51) | MAP3K14ADRA2ADRD2DRD3HCRTR2 | |
| SCHEMBL24075122 | 0.73 | MAP3K14 (0.51) | MAP3K14ADRA2ADRD2DRD3HCRTR2 | |
| SCHEMBL21436437 | 0.73 | MAP3K14 (0.51) | MAP3K14ADRA2ADRD2DRD3HCRTR2 | |
| SCHEMBL13198495 | 0.73 | MAP3K14 (0.51) | MAP3K14ADRA2ADRD2DRD3HCRTR2 | |
| SCHEMBL8912565 | 0.73 | MAP3K14 (0.51) | MAP3K14ADRA2ADRD2DRD3HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5194442-A | 2,3,4,5-tetrahydro-1-benzoxepins, the use thereof and pharmaceutical products based on these compounds | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-03-16 | — | — | US | disclosed |
| EP-0360131-A1 | 2,3,4,5-Tetrahydro-1-benzoxepines, method for their preparation, their use and pharmaceutical compositions based on these compounds | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-03-28 | — | — | EP | disclosed |