Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CDK4 | P11802 | 7/20 | 0.47 |
| ▸ | CCND1 | P24385 | 7/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.44 |
| ▸ | CDK2 | P24941 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7428957 | 0.89 | HSD17B10 (0.50) | HSD17B10HPGDUSP2ALDH1A1KDM4E | |
| SCHEMBL5847534 | 0.86 | HSD17B10 (0.48) | HSD17B10HPGDUSP2ALDH1A1KDM4E | |
| SCHEMBL9585508 | 0.85 | CDK4 (0.48) | HSD17B10HPGDUSP2ALDH1A1KDM4E | |
| SCHEMBL9586206 | 0.83 | CDK4 (0.47) | HSD17B10HPGDUSP2ALDH1A1KDM4E | |
| SCHEMBL7424620 | 0.80 | CDK4 (0.45) | HSD17B10HPGDUSP2ALDH1A1KDM4E | |
| SCHEMBL7434089 | 0.80 | BCHE (0.45) | HSD17B10KDM4ECYP1A2LMNACDK4 | |
| SCHEMBL5421535 | 0.77 | HSD17B10 (0.52) | HSD17B10HPGDUSP2ALDH1A1KDM4E | |
| SCHEMBL7326732 | 0.77 | HSD17B10 (0.52) | HSD17B10HPGDUSP2ALDH1A1KDM4E | |
| SCHEMBL9586314 | 0.74 | MCL1 (0.46) | LMNAMCL1TP53MAPT | |
| SCHEMBL5405488 | 0.73 | HTR2C (0.63) | HSD17B10HPGDUSP2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5223625-A | Antagonistic acitivity on 5-hydroxytryptamine receptors | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1993-06-29 | — | — | US | disclosed |
| EP-0377238-A1 | New annelated indolo (3,2-c)-lactams | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1990-07-11 | — | — | EP | disclosed |