Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 18/20 | 0.54 |
| ▸ | RAF1 | P04049 | 12/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL959569 | 0.71 | MAP2K1 (0.54) | MAP2K1RAF1CYP3A4CYP2C9 | |
| SCHEMBL961031 | 0.71 | MAP2K1 (0.54) | MAP2K1RAF1CYP3A4CYP2C9 | |
| SCHEMBL958976 | 0.71 | MAP2K1 (0.57) | MAP2K1RAF1CYP3A4CYP2C9BRAF | |
| SCHEMBL14250641 | 0.70 | MAP2K1 (0.75) | MAP2K1RAF1CYP3A4CYP2C9BRAF | |
| SCHEMBL958763 | 0.70 | MAP2K1 (1.00) | MAP2K1RAF1CYP3A4CYP2C9BRAF | |
| SCHEMBL958868 | 0.69 | MAP2K1 (0.51) | MAP2K1RAF1CYP3A4CYP2C9BRAF | |
| SCHEMBL12694009 | 0.69 | MAP2K1 (0.86) | MAP2K1RAF1CYP3A4CYP2C9BRAF | |
| SCHEMBL959681 | 0.69 | MAP2K1 (0.73) | MAP2K1RAF1CYP3A4CYP2C9BRAF | |
| SCHEMBL25144041 | 0.68 | MAP2K1 (0.65) | MAP2K1RAF1CYP3A4CYP2C9BRAF | |
| SCHEMBL959595 | 0.68 | MAP2K1 (0.55) | MAP2K1RAF1CYP3A4CYP2C9BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8569378-B2 | p27 protein inducer | Sakai, Toshiyuki (JP) | 2013-10-29 | — | — | US | disclosed |
| US-20110009398-A1 | p27 Protein Inducer | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2011-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110009398-A1 | p27 Protein Inducer | CDKN1A, CDK2, SKP2 | MAP2K1 1179/4885RAF1 1656/4885CYP3A4 925/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.