Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 12/20 | 0.52 |
| ▸ | MAOA | P21397 | 7/20 | 0.48 |
| ▸ | MAOB | P27338 | 7/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7548321 | 0.82 | NISCH (0.66) | NISCHMAOAMAOBCYP2D6ADRA2A | |
| Midaglizole SCHEMBL114554 | 0.79 | NISCH (0.74) | NISCHMAOAMAOBCYP2D6ADRA2A | |
| Midaglizole SCHEMBL30029057 | 0.79 | NISCH (0.74) | NISCHMAOAMAOBCYP2D6ADRA2A | |
| Midaglizole SCHEMBL9403180 | 0.77 | NISCH (0.72) | NISCHMAOAMAOBCYP2D6ADRA2A | |
| Midaglizole SCHEMBL752697 | 0.77 | NISCH (0.72) | NISCHMAOAMAOBCYP2D6ADRA2A | |
| SCHEMBL7550085 | 0.76 | NISCH (0.51) | NISCHMAOAMAOBCYP2D6ADRA2A | |
| SCHEMBL7547444 | 0.76 | NISCH (0.51) | NISCHMAOAMAOBCYP2D6ADRA2A | |
| SCHEMBL9588018 | 0.76 | NISCH (0.48) | NISCHMAOAMAOBCYP2D6ADRA2A | |
| SCHEMBL7547494 | 0.75 | NISCH (0.50) | NISCHMAOAMAOBCYP2D6ADRA2A | |
| SCHEMBL7548769 | 0.74 | NISCH (0.51) | NISCHMAOAMAOBCYP2D6ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5262430-A | Antidiabetic agent lowers blood glucose in mammals in type 2 non insulin dependent diabetes | NOVO NORDISK A/S (DK) | 1993-11-16 | — | — | US | disclosed |