Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC29A1 | Q99808 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | DRD3 | P35462 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.46 |
| ▸ | EBP | Q15125 | 2/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.46 |
| ▸ | LDHA | P00338 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9591281 | 0.99 | SLC29A1 (0.51) | SLC29A1SMN1; SMN2LMNADRD3KMT2A | |
| SCHEMBL9588640 | 0.81 | SLC29A1 (0.48) | SLC29A1SMN1; SMN2LMNADRD3KMT2A | |
| Hydrochloric Acid SCHEMBL9589396 | 0.80 | SLC29A1 (0.47) | SLC29A1SMN1; SMN2LMNADRD3KMT2A | |
| SCHEMBL9588553 | 0.79 | SLC18A3 (0.49) | DRD3SLC18A3DRD2 | |
| SCHEMBL9590109 | 0.79 | DRD3 (0.59) | LMNADRD3KMT2AMEN1SIGMAR1 | |
| Ethylbenzene SCHEMBL9590427 | 0.78 | SLC18A3 (0.62) | SMN1; SMN2KMT2AMEN1KDM4EGAA | |
| Hydrochloric Acid SCHEMBL9589481 | 0.77 | DRD3 (0.58) | SMN1; SMN2LMNADRD3KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL9589159 | 0.77 | SLC18A3 (0.48) | DRD3SLC18A3DRD2 | |
| Ethylbenzene SCHEMBL9588725 | 0.77 | SLC18A3 (0.60) | KMT2AMEN1KDM4EGAASLC18A3 | |
| SCHEMBL27806086 | 0.76 | APP (0.55) | KDM4ELDHA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5190946-A | Piperazine compounds restore sensitivity to drug resistant cancer cells | HOFFMANN-LA ROCHE INC. (US) | 1993-03-02 | — | — | US | claimed |
| EP-0443569-A2 | Diamine derivatives and their use in oncology | F. HOFFMANN-LA ROCHE AG (CH) | 1991-08-28 | — | — | EP | claimed |
| US-5190946-A | Piperazine compounds restore sensitivity to drug resistant cancer cells | HOFFMANN-LA ROCHE INC. (US) | 1993-03-02 | — | — | US | disclosed |
| EP-0443569-A2 | Diamine derivatives and their use in oncology | F. HOFFMANN-LA ROCHE AG (CH) | 1991-08-28 | — | — | EP | disclosed |