Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.49 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.46 |
| ▸ | CPT1A | P50416 | 3/20 | 0.45 |
| ▸ | CPT1B | Q92523 | 3/20 | 0.45 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.45 |
| ▸ | SLC2A1 | P11166 | 5/20 | 0.43 |
| ▸ | SLC2A3 | P11169 | 5/20 | 0.43 |
| ▸ | SLC2A4 | P14672 | 5/20 | 0.43 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24273099 | 0.85 | MCL1 (0.61) | MCL1PTGER4CPT1ACPT1BKDM4C | |
| SCHEMBL962070 | 0.85 | ELANE (0.51) | MCL1PTGER4SLC2A1SLC2A3SLC2A4 | |
| SCHEMBL3784936 | 0.80 | CPT1A (0.68) | MCL1PTGER4CPT1ACPT1BKDM4C | |
| SCHEMBL12885227 | 0.79 | CNR1 (0.54) | PTGER4CPT1ACPT1BSLC2A1SLC2A3 | |
| SCHEMBL1218593 | 0.79 | CNR1 (0.54) | PTGER4CPT1ACPT1BSLC2A1SLC2A3 | |
| SCHEMBL12885237 | 0.78 | CNR1 (0.44) | PTGER4CPT1ACPT1BSLC2A1SLC2A3 | |
| SCHEMBL1218381 | 0.78 | CNR1 (0.44) | PTGER4CPT1ACPT1BSLC2A1SLC2A3 | |
| SCHEMBL1218252 | 0.77 | SLC2A1 (0.41) | PTGER4SLC2A1SLC2A3SLC2A4P2RY14 | |
| SCHEMBL1218213 | 0.76 | PTGER4 (0.71) | PTGER4CYP3A4CYP2D6CYP1A2CYP2C9 | |
| SCHEMBL14584154 | 0.76 | SLC22A12 (0.52) | MCL1CYP3A4CYP2D6CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8071628-B2 | Indazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-12-06 | — | — | US | disclosed |
| US-20110015234-A1 | INDAZOLE DERIVATIVES | ACKERMANN JEAN | 2011-01-20 | — | — | US | disclosed |
| US-7858645-B2 | Indazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2010-12-28 | — | — | US | disclosed |
| EP-2079703-A1 | INDAZOLE DERIVATIVES USEFUL AS L-CPT1 INHIBITORS | F. Hoffmann-Roche AG (CH) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008052898-A1 | INDAZOLE DERIVATIVES USEFUL AS L-CPT1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-05-08 | — | — | WO | disclosed |
| US-20080103182-A1 | INDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG, A SWISS COMPANY (CH) | 2008-05-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080103182-A1 | INDAZOLE DERIVATIVES | CPT1A, CPT1B, CES1 | MCL1 1482/4885PTGER4 1048/4885CPT1A 1/4885 |
| US-20110015234-A1 | INDAZOLE DERIVATIVES | CPT1A, CPT1B, CES1 | MCL1 1482/4885PTGER4 1048/4885CPT1A 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.