Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA4 | P48058 | 13/20 | 1.00 |
| ▸ | GRIA2 | P42262 | 8/20 | 1.00 |
| ▸ | GRIA1 | P42261 | 2/20 | 1.00 |
| ▸ | GRIA3 | P42263 | 2/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2134262 | 1.00 | GRIA4 (1.00) | GRIA4GRIA2GRIA1GRIA3KCNH2 | |
| SCHEMBL5877782 | 0.96 | GRIA4 (0.91) | GRIA4GRIA2GRIA1GRIA3 | |
| SCHEMBL13255761 | 0.88 | GRIA4 (0.87) | GRIA4GRIA2GRIA1GRIA3 | |
| SCHEMBL5992693 | 0.88 | GRIA4 (0.87) | GRIA4GRIA2GRIA1GRIA3 | |
| SCHEMBL6782571 | 0.87 | GRIA4 (0.76) | GRIA4GRIA2GRIA1GRIA3KCNH2 | |
| SCHEMBL6565117 | 0.83 | GRIA4 (0.77) | GRIA4GRIA2GRIA1GRIA3 | |
| SCHEMBL5878459 | 0.82 | GRIA4 (1.00) | GRIA4GRIA2GRIA1GRIA3 | |
| SCHEMBL5878433 | 0.82 | GRIA4 (1.00) | GRIA4GRIA2GRIA1GRIA3 | |
| SCHEMBL5878300 | 0.81 | GRIA4 (0.75) | GRIA4GRIA2GRIA1GRIA3 | |
| SCHEMBL5877677 | 0.81 | GRIA4 (0.68) | GRIA4GRIA2GRIA1GRIA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8173820-B2 | Compounds which potentiate the AMPA receptor and uses thereof in medicine | GLAXO GROUP LIMITED (GB) | 2012-05-08 | — | — | US | disclosed |
| US-20110021578-A1 | Compounds which Potentiate the AMPA Receptor and Uses Thereof in Medicine | GLAXO GROUP LIMITED (GB) | 2011-01-27 | — | — | US | disclosed |
| WO-2010087982-A1 | GLUR2 RECEPTOR MODULATORS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2010-08-05 | — | — | WO | disclosed |
| US-20090270508-A1 | GluR2 receptor modulators | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2009-10-29 | — | — | US | disclosed |
| US-20070293573-A1 | GLU2 RECEPTOR MODULATORS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-12-20 | — | — | US | disclosed |
| WO-2007101116-A2 | GLUR2 RECEPTOR MODULATORS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2007-09-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021578-A1 | Compounds which Potentiate the AMPA Receptor and Uses Thereof in Medicine | GRIN1, GRM1, GRM2 | GRIA4 13/4885GRIA2 20/4885GRIA1 12/4885 |
| US-20070293573-A1 | GLU2 RECEPTOR MODULATORS | GRM2, GRIK2, GRIA2 | GRIA4 15/4885GRIA2 3/4885GRIA1 17/4885 |
| US-20090270508-A1 | GluR2 receptor modulators | GRM2, GRIK2, GRIN2A | GRIA4 16/4885GRIA2 4/4885GRIA1 19/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.