Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 3/20 | 0.56 |
| ▸ | TOP2B | Q02880 | 3/20 | 0.56 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | FBP1 | P09467 | 1/20 | 0.38 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9594388 | 0.96 | TOP2A (0.56) | TOP2ATOP2BCSF1RTP53MAPT | |
| SCHEMBL9594330 | 0.94 | TOP2A (0.56) | TOP2ATOP2BCSF1RTP53MAPT | |
| SCHEMBL9595752 | 0.94 | TOP2A (0.58) | TOP2ATOP2BCSF1RTP53MAPT | |
| SCHEMBL9593549 | 0.91 | TOP2A (0.57) | TOP2ATOP2BCSF1RTP53MAPT | |
| SCHEMBL9593668 | 0.91 | TOP2A (0.57) | TOP2ATOP2BCSF1RTP53MAPT | |
| SCHEMBL9594317 | 0.91 | TOP2A (0.55) | TOP2ATOP2BTP53MAPTPDPK1 | |
| SCHEMBL9594448 | 0.90 | TOP2A (0.56) | TOP2ATOP2BCSF1RTP53MAPT | |
| SCHEMBL9593497 | 0.89 | TOP2A (0.57) | TOP2ATOP2BCSF1RTP53MAPT | |
| SCHEMBL9594484 | 0.89 | TOP2A (0.57) | TOP2ATOP2BCSF1RTP53MAPT | |
| SCHEMBL9592851 | 0.89 | TOP2A (0.63) | TOP2ATOP2BKDM1AACHEPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991005770-A1 | POTENTIAL ANTICANCER AGENTS DERIVED FROM ACRIDINE | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1991-05-02 | — | — | WO | claimed |
| US-5229395-A | Potential anticancer agents derived from acridine | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1993-07-20 | — | — | US | disclosed |
| WO-1991005770-A1 | POTENTIAL ANTICANCER AGENTS DERIVED FROM ACRIDINE | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1991-05-02 | — | — | WO | disclosed |