Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 2/20 | 0.41 |
| ▸ | ELANE | P08246 | 2/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | CTSG | P08311 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9599494 | 1.00 | SMN1; SMN2 (0.46) | SMN1; SMN2NPC1RAB9AGAAMAPK1 | |
| SCHEMBL4397158 | 0.76 | SMN1; SMN2 (0.46) | SMN1; SMN2NPC1RAB9AGAAMAPK1 | |
| SCHEMBL9599489 | 0.76 | SMN1; SMN2 (0.46) | SMN1; SMN2NPC1RAB9AGAAMAPK1 | |
| SCHEMBL4397156 | 0.76 | SMN1; SMN2 (0.46) | SMN1; SMN2NPC1RAB9AGAAMAPK1 | |
| SCHEMBL7456053 | 0.74 | PREP (0.52) | SMN1; SMN2NPC1RAB9AKMT2ANPSR1 | |
| SCHEMBL7460642 | 0.74 | PREP (0.52) | SMN1; SMN2NPC1RAB9AKMT2ANPSR1 | |
| SCHEMBL7456048 | 0.74 | PREP (0.52) | SMN1; SMN2NPC1RAB9AKMT2ANPSR1 | |
| SCHEMBL7460647 | 0.74 | PREP (0.52) | SMN1; SMN2NPC1RAB9AKMT2ANPSR1 | |
| SCHEMBL8790173 | 0.73 | PREP (0.48) | SMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL928745 | 0.72 | SMN1; SMN2 (0.47) | SMN1; SMN2NPC1RAB9AGAAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5200406-A | Nootropic agents; learning enhancement | I.S.F. SOCIETA PER AZIONI (IT) | 1993-04-06 | — | — | US | disclosed |
| US-5130319-A | Cognition activators for memory disorders | I.S.F. SOCIETA PER AZIONI (IT) | 1992-07-14 | — | — | US | disclosed |
| US-5053422-A | Learning-memory enhancers; nootropic agents | I.S.F. SOCIETA PER AZIONI (IT) | 1991-10-01 | — | — | US | disclosed |
| EP-0335483-A2 | Condensed imidazole derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them. | ISF SOCIETA PER AZIONI (IT) | 1989-10-04 | — | — | EP | disclosed |