Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 2/20 | 0.40 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.32 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.30 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31314909 | 0.88 | GRIK1 (0.44) | GRIK1GRIK2CHRM1CHRM3AKR1A1 | |
| SCHEMBL5245011 | 0.71 | — | — | |
| SCHEMBL455293 | 0.71 | — | — | |
| SCHEMBL3107148 | 0.71 | — | — | |
| SCHEMBL16072764 | 0.70 | CHRM1 (0.53) | GRIK1GRIK2CHRM1CHRM3CHRM2 | |
| SCHEMBL4816341 | 0.70 | GRIK1 (0.41) | GRIK1GRIK2CHRM1CHRM3AKR1A1 | |
| SCHEMBL10946718 | 0.70 | GRIK1 (0.43) | GRIK1GRIK2CHRM1CHRM3AKR1A1 | |
| SCHEMBL15551689 | 0.70 | GRIK1 (0.50) | GRIK1GRIK2CHRM1 | |
| SCHEMBL10477518 | 0.70 | GRIK1 (0.50) | GRIK1GRIK2CHRM1 | |
| SCHEMBL10946710 | 0.69 | GRIK1 (0.53) | GRIK1GRIK2CHRM1CHRM3AKR1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993013104-A1 | C.N.S. ACTIVE TRICYCLIC THIENOPYRIDINE DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 1993-07-08 | — | — | WO | disclosed |