Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 13/20 | 0.73 |
| ▸ | TNF | P01375 | 1/20 | 0.54 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | GALR3 | O60755 | 1/20 | 0.47 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10588668 | 0.93 | TLR7 (0.64) | TLR7TNFTLR8RAB9AGALR3 | |
| SCHEMBL10588666 | 0.88 | MEN1 (0.58) | TLR7TNFTLR8ALDH1A1LMNA | |
| SCHEMBL10733278 | 0.87 | TLR7 (0.56) | TLR7TNFALDH1A1MEN1KMT2A | |
| SCHEMBL10734376 | 0.86 | TLR7 (0.55) | TLR7TNFTLR8RAB9AGALR3 | |
| SCHEMBL3195859 | 0.84 | TLR7 (1.00) | TLR7TLR8 | |
| SCHEMBL6107502 | 0.83 | TLR7 (0.52) | TLR7TNFRAB9AALDH1A1LMNA | |
| SCHEMBL211223 | 0.83 | TLR7 (0.51) | TLR7TLR8 | |
| SCHEMBL13533466 | 0.82 | TLR7 (0.68) | TLR7TNFTLR8 | |
| SCHEMBL9602876 | 0.82 | TLR7 (0.51) | TLR7TNFTLR8ALDH1A1LMNA | |
| Bromide SCHEMBL842506 | 0.82 | TLR7 (0.56) | TLR7TNFTLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0310950-B1 | Quinoline intermediates for the synthesis of 1H-imidazo[4,5-c]quinolines and 1H-imidazo[4,5-c]quinolin-4-amimes | RIKER LABORATORIES, INC. (US) | 1993-01-13 | — | — | EP | disclosed |
| EP-0145340-B1 | 1H-Imidazo[4,5-c]quinolines and 1H-imidazo[4,5-c]quinolin-4-amines | RIKER LABORATORIES, INC. (US) | 1990-01-24 | — | — | EP | disclosed |
| EP-0310950-A1 | Quinoline intermediates for the synthesis of 1H-imidazo[4,5-c]quinolines and 1H-imidazo[4,5-c]quinolin-4-amimes | RIKER LABORATORIES, INC. (US) | 1989-04-12 | — | — | EP | disclosed |
| US-4689338-A | 1H-Imidazo[4,5-c]quinolin-4-amines and antiviral use | RIKER LABORATORIES, INC. (US) | 1987-08-25 | — | — | US | disclosed |
| EP-0145340-A2 | 1H-Imidazo[4,5-c]quinolines and 1H-imidazo[4,5-c]quinolin-4-amines | RIKER LABORATORIES, INC. (US) | 1985-06-19 | — | — | EP | disclosed |