Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | CTSG | P08311 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9602059 | 0.86 | ELANE (0.39) | ELANECTSGALDH1A1MAPTKDM4E | |
| SCHEMBL9602954 | 0.85 | ELANE (0.37) | ELANECTSGALDH1A1MAPTKDM4E | |
| SCHEMBL9602575 | 0.84 | ELANE (0.36) | ELANECTSGALDH1A1MAPTKDM4E | |
| SCHEMBL9603125 | 0.79 | ELANE (0.33) | ELANECTSGALDH1A1MAPTTHRB | |
| SCHEMBL9602604 | 0.79 | MAPT (0.38) | ELANECTSGALDH1A1MAPTKMT2A | |
| SCHEMBL9602994 | 0.78 | MAPT (0.35) | ELANECTSGALDH1A1MAPTTHRB | |
| SCHEMBL10677033 | 0.77 | MAPT (0.39) | ELANECTSGALDH1A1MAPTKDM4E | |
| SCHEMBL9603082 | 0.76 | MAPT (0.38) | ELANECTSGALDH1A1MAPTTHRB | |
| SCHEMBL9602659 | 0.72 | MAPT (0.35) | ELANECTSGALDH1A1MAPTTHRB | |
| SCHEMBL9603006 | 0.71 | MAPT (0.33) | ELANECTSGALDH1A1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5217963-A | Antiischemic, antiepileptic agent | CIBA-GEIGY CORPORATION (US) | 1993-06-08 | — | — | US | disclosed |
| US-5057506-A | Anticonvulsants, antispasmodic and antischemic agents | CIBA-GEIGY CORPORATION (US) | 1991-10-15 | — | — | US | disclosed |
| US-4906621-A | Certain 2-carboxypiperidyl-alkylene phosphonic acids and esters thereof useful for the treatment of disorders responsive to N-methyl-D-aspartate receptor blockade | CIBA-GEIGY CORPORATION (US) | 1990-03-06 | — | — | US | disclosed |