Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 3/20 | 0.40 |
| ▸ | MET | P08581 | 3/20 | 0.40 |
| ▸ | TEK | Q02763 | 3/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4439330 | 0.89 | KDR (0.79) | KDR | |
| SCHEMBL4445915 | 0.88 | KDR (0.68) | KDRKDM4E | |
| SCHEMBL14147261 | 0.82 | KDR (0.59) | KDRAURKAMETTEKAURKB | |
| SCHEMBL9605539 | 0.81 | KDR (0.74) | KDR | |
| SCHEMBL4436645 | 0.81 | KDR (0.77) | KDR | |
| SCHEMBL9605542 | 0.80 | KDR (0.72) | KDRKDM4E | |
| SCHEMBL9605549 | 0.78 | KDR (1.00) | KDRAURKAMETTEKAURKB | |
| SCHEMBL9605536 | 0.78 | KDR (1.00) | KDRAURKAMETTEKAURKB | |
| SCHEMBL14122430 | 0.78 | KDR (0.87) | KDR | |
| SCHEMBL9605553 | 0.76 | KDR (1.00) | KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118088-B1 | Heterocyclic compounds and their use in treating inflammation, angiogenesis and cancer | AMGEN INC (US) | 2012-05-30 | — | — | EP | disclosed |