Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 15/20 | 0.57 |
| ▸ | PIK3CD | O00329 | 15/20 | 0.55 |
| ▸ | PIK3CB | P42338 | 10/20 | 0.55 |
| ▸ | PIK3CG | P48736 | 10/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL960643 | 0.86 | PIK3CA (0.70) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL959704 | 0.83 | PIK3CA (0.80) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| Hydrochloric Acid SCHEMBL1497317 | 0.82 | PIK3CA (0.79) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL960919 | 0.76 | PIK3CA (0.87) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL964649 | 0.75 | PIK3CA (0.86) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL1181251 | 0.75 | PIK3CA (0.74) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL964018 | 0.75 | PIK3CA (0.70) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL12166287 | 0.75 | PIK3CA (0.59) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL959193 | 0.74 | PIK3CA (0.71) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL1181569 | 0.74 | PIK3CA (0.73) | PIK3CAPIK3CDPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7872003-B2 | Pharmaceutical compounds | F. HOFFMANN-LA ROCHE AG (CH) | 2011-01-18 | — | — | US | claimed |
| US-20080207609-A1 | Pharmaceutical compounds | PLRAMED LIMITED (GB) | 2008-08-28 | — | — | US | claimed |
| US-7872003-B2 | Pharmaceutical compounds | F. HOFFMANN-LA ROCHE AG (CH) | 2011-01-18 | — | — | US | disclosed |
| US-20080207609-A1 | Pharmaceutical compounds | PLRAMED LIMITED (GB) | 2008-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207609-A1 | Pharmaceutical compounds | PIK3CA, JAK2, PIK3R1 | PIK3CA 1/4885PIK3CD 12/4885PIK3CB 14/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.