Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 14/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14430730 | 0.94 | PTGER4 (0.48) | PTGER4CYP1A2CYP2D6KDM4EALDH1A1 | |
| SCHEMBL2296371 | 0.92 | PTGER4 (0.55) | PTGER4CYP1A2CYP2D6PTGDR2KDM4E | |
| SCHEMBL13942575 | 0.90 | PTGER4 (0.61) | PTGER4CYP1A2CYP2D6PTGDR2 | |
| SCHEMBL9606712 | 0.90 | PTGER4 (0.42) | PTGER4CYP1A2CYP2D6KDM4EALDH1A1 | |
| SCHEMBL1590079 | 0.89 | PTGER4 (0.52) | PTGER4CYP1A2CYP2D6PTGDR2KDM4E | |
| SCHEMBL9947633 | 0.88 | PTGER4 (0.51) | PTGER4CYP1A2CYP2D6PTGDR2KDM4E | |
| SCHEMBL14430790 | 0.86 | PTGER4 (0.47) | PTGER4CYP1A2CYP2D6PTGDR2 | |
| SCHEMBL9947668 | 0.86 | PTGER4 (0.54) | PTGER4CYP1A2CYP2D6PTGDR2 | |
| SCHEMBL9606784 | 0.84 | PTGER4 (0.66) | PTGER4PTGDR2 | |
| SCHEMBL14430731 | 0.84 | PTGER4 (0.47) | PTGER4CYP1A2CYP2D6KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979316-B1 | BENZO (F) ISOINDOL-2-YLPHENYL ACETIC ACID DERIVATIVES AS EP4 RECEPTOR AGONISTS | GLAXO GROUP LTD (GB) | 2012-07-11 | — | — | EP | disclosed |
| EP-2457897-A1 | BENZO (F) ISOINDOL-2-YLPHENYL ACETIC ACID DERIVATIVES AS EP4 RECEPTOR AGONISTS | Glaxo Group Limited (GB) | 2012-05-30 | — | — | EP | disclosed |