Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.45 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | PREP | P48147 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9640948 | 1.00 | POLB (0.60) | POLBSMN1; SMN2CYP2C19PSEN1PSEN2 | |
| SCHEMBL7042009 | 1.00 | POLB (0.60) | POLBSMN1; SMN2CYP2C19PSEN1PSEN2 | |
| SCHEMBL10746321 | 1.00 | POLB (0.60) | POLBSMN1; SMN2CYP2C19PSEN1PSEN2 | |
| SCHEMBL71528 | 0.89 | POLB (0.62) | POLBSMN1; SMN2CYP2C19PSEN1PSEN2 | |
| SCHEMBL28269 | 0.89 | POLB (0.62) | POLBSMN1; SMN2CYP2C19PSEN1PSEN2 | |
| SCHEMBL7016734 | 0.89 | POLB (0.62) | POLBSMN1; SMN2CYP2C19PSEN1PSEN2 | |
| SCHEMBL29878 | 0.89 | POLB (0.62) | POLBSMN1; SMN2CYP2C19PSEN1PSEN2 | |
| SCHEMBL71529 | 0.89 | POLB (0.62) | POLBSMN1; SMN2CYP2C19PSEN1PSEN2 | |
| SCHEMBL31037789 | 0.89 | POLB (0.62) | POLBSMN1; SMN2CYP2C19PSEN1PSEN2 | |
| SCHEMBL7489292 | 0.89 | POLB (0.62) | POLBSMN1; SMN2CYP2C19PSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2457896-A1 | Tripeptides as caspase modulators | Idun Pharmaceuticals, Inc. (US) | 2012-05-30 | — | — | EP | disclosed |
| EP-2457895-A1 | Tetrapeptide analogs | Idun Pharmaceuticals, Inc. (US) | 2012-05-30 | — | — | EP | disclosed |