Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | EP300 | Q09472 | 1/20 | 0.46 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | NCF1 | P14598 | 2/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.34 |
| ▸ | TLR4 | O00206 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL535725 | 0.85 | IDO1 (0.46) | IDO1EP300KAT8GAANCF1 | |
| SCHEMBL535774 | 0.82 | IDO1 (0.44) | IDO1EP300KAT8GAAALDH1A1 | |
| SCHEMBL20663706 | 0.82 | IDO1 (0.44) | IDO1EP300KAT8KDR | |
| SCHEMBL17659975 | 0.80 | MAPK14 (0.37) | PDGFRBPDGFRA | |
| SCHEMBL9609811 | 0.80 | CHEK1 (0.38) | EP300KAT8GAAALDH1A1PDGFRB | |
| SCHEMBL6545883 | 0.79 | IDO1 (0.44) | IDO1EP300KAT8ALDH1A1PDGFRA | |
| SCHEMBL16829073 | 0.79 | MAPK14 (0.50) | KDR | |
| SCHEMBL5257415 | 0.78 | IDO1 (0.52) | IDO1EP300KAT8GAAALDH1A1 | |
| SCHEMBL13331029 | 0.78 | GCK (0.49) | — | |
| SCHEMBL15517417 | 0.77 | SRC (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9242960-B2 | P38MAP kinase inhibitors | Respivert, Ltd. (GB) | 2016-01-26 | — | — | US | disclosed |
| US-20140228410-A1 | P38MAP KINASE INHIBITORS | RESPIVERT LTD. (GB) | 2014-08-14 | — | — | US | disclosed |
| US-8642773-B2 | P38MAP kinase inhibitor | RESPIVERT LTD. (GB) | 2014-02-04 | — | — | US | disclosed |
| US-20120136031-A1 | P38MAP KINASE INHIBITOR | RESPIVERT LTD. (GB) | 2012-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140228410-A1 | P38MAP KINASE INHIBITORS | MAPK1, MAP3K1, MAP3K11 | IDO1 2059/4885EP300 1520/4885KAT8 1438/4885 |
| US-20120136031-A1 | P38MAP KINASE INHIBITOR | MAPK1, MAP3K1, MAP3K11 | IDO1 2120/4885EP300 1524/4885KAT8 1415/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.