Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 7/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.42 |
| ▸ | BCL2 | P10415 | 2/20 | 0.42 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.42 |
| ▸ | BAD | Q92934 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9614076 | 0.91 | HTR1B (0.49) | HTR1BKDM4EALDH1A1HPGDMCL1 | |
| SCHEMBL9613987 | 0.90 | HTR1B (0.46) | HTR1BKDM4EALDH1A1HPGDHTR1D | |
| SCHEMBL9613816 | 0.90 | HTR1B (0.46) | HTR1BKDM4EALDH1A1HPGDMCL1 | |
| SCHEMBL9613879 | 0.89 | MCL1 (0.46) | HTR1BKDM4EALDH1A1HPGDMCL1 | |
| SCHEMBL9613865 | 0.89 | HTR1B (0.45) | HTR1BKDM4EALDH1A1HPGDMCL1 | |
| SCHEMBL9613777 | 0.88 | HTR1B (0.44) | HTR1BKDM4EALDH1A1HPGDMCL1 | |
| SCHEMBL9613949 | 0.85 | HTR1B (0.45) | HTR1BKDM4EALDH1A1HPGDMCL1 | |
| SCHEMBL9613717 | 0.84 | MCL1 (0.45) | HTR1BKDM4EALDH1A1HPGDMCL1 | |
| SCHEMBL9614132 | 0.82 | HTR1B (0.47) | HTR1BKDM4EALDH1A1HPGDMCL1 | |
| SCHEMBL9613926 | 0.82 | HTR1B (0.43) | HTR1BKDM4EALDH1A1HPGDMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135947-A | Treatment of depression, eating disorders, and alcoholism | ELI LILLY AND COMPANY (US) | 1992-08-04 | — | — | US | disclosed |
| EP-0288188-B1 | 1-PHENYL-3-NAPHTHALENYLOXY-PROPANAMINES | ELI LILLY AND COMPANY (US) | 1991-10-16 | — | — | EP | disclosed |