Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | HTR1B | P28222 | 6/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.50 |
| ▸ | OGG1 | O15527 | 1/20 | 0.49 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.46 |
| ▸ | HTR1D | P28221 | 2/20 | 0.46 |
| ▸ | BCL2 | P10415 | 2/20 | 0.45 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.45 |
| ▸ | BAD | Q92934 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL541161 | 0.93 | HTR1B (0.60) | KMT2AKDM4EALDH1A1HPGDTDP1 | |
| SCHEMBL12071826 | 0.93 | HTR1B (0.60) | KMT2AKDM4EALDH1A1HPGDTDP1 | |
| Isophthalic Acid SCHEMBL27276104 | 0.92 | MRGPRX4 (0.56) | KMT2AKDM4EALDH1A1HPGDTDP1 | |
| Hydrochloric Acid SCHEMBL28883801 | 0.91 | HTR1B (0.58) | KMT2AKDM4EALDH1A1HPGDTDP1 | |
| Hydrochloric Acid SCHEMBL28370503 | 0.91 | HTR1B (0.58) | KMT2AKDM4EALDH1A1HPGDTDP1 | |
| Oxalic Acid SCHEMBL9614031 | 0.91 | KMT2A (0.52) | KMT2AKDM4EALDH1A1HPGDTDP1 | |
| Oxalic Acid SCHEMBL9614065 | 0.89 | KMT2A (0.53) | KMT2AKDM4EALDH1A1HPGDTDP1 | |
| Oxalic Acid SCHEMBL9613778 | 0.89 | KMT2A (0.53) | KMT2AKDM4EALDH1A1HPGDTDP1 | |
| Oxalic Acid SCHEMBL9613902 | 0.86 | SLC6A2 (0.51) | KMT2AKDM4EALDH1A1HPGDTDP1 | |
| Oxalic Acid SCHEMBL9614095 | 0.84 | KMT2A (0.53) | KMT2AKDM4EALDH1A1HPGDTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1020093-C | 1-phenyl -3-naphthalenyloxypropanamines | LILLY CO ELI (US) | 1993-03-17 | — | — | CN | disclosed |
| US-5135947-A | Treatment of depression, eating disorders, and alcoholism | ELI LILLY AND COMPANY (US) | 1992-08-04 | — | — | US | disclosed |
| EP-0288188-B1 | 1-PHENYL-3-NAPHTHALENYLOXY-PROPANAMINES | ELI LILLY AND COMPANY (US) | 1991-10-16 | — | — | EP | disclosed |
| EP-0288188-A1 | 1-Phenyl-3-naphthalenyloxy-propanamines | ELI LILLY AND COMPANY (US) | 1988-10-26 | — | — | EP | disclosed |
| CN-88102018-A | 1-Phenyl-3-naphthyloxypropylamine | — | 1988-10-26 | — | — | CN | disclosed |