Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Flecainide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN5A known ✓ | Q14524 | 1/20 | 0.93 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.93 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.93 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.93 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.93 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.93 |
| ▸ | TSHR | P16473 | 1/20 | 0.93 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.93 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.93 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.93 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.93 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.93 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.93 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.93 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.93 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.93 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Flecainide SCHEMBL121583 | 1.00 | SMN1; SMN2 (1.00) | SMN1; SMN2LMNANPSR1PMP22CYP1A2 | |
| Flecainide SCHEMBL308966 | 1.00 | SMN1; SMN2 (1.00) | SMN1; SMN2LMNANPSR1PMP22CYP1A2 | |
| Flecainide SCHEMBL14970 | 0.96 | CYP1A2 (1.00) | SMN1; SMN2LMNANPSR1PMP22CYP1A2 | |
| (R)-Flecainide SCHEMBL14971 | 0.96 | CYP1A2 (1.00) | SMN1; SMN2LMNANPSR1PMP22CYP1A2 | |
| Flecainide SCHEMBL29385957 | 0.96 | CYP1A2 (1.00) | SMN1; SMN2LMNANPSR1PMP22CYP1A2 | |
| Flecainide SCHEMBL17799127 | 0.96 | CYP1A2 (1.00) | SMN1; SMN2LMNANPSR1PMP22CYP1A2 | |
| Acetic Acid SCHEMBL10469403 | 0.95 | SMN1; SMN2 (0.91) | SMN1; SMN2LMNANPSR1PMP22CYP1A2 | |
| Acetic Acid SCHEMBL10468143 | 0.95 | SMN1; SMN2 (0.91) | SMN1; SMN2LMNANPSR1PMP22CYP1A2 | |
| Flecainide SCHEMBL5569654 | 0.95 | CYP1A2 (0.98) | SMN1; SMN2LMNANPSR1PMP22CYP1A2 | |
| Flecainide SCHEMBL5569649 | 0.95 | CYP1A2 (0.98) | SMN1; SMN2LMNANPSR1PMP22CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0460064-A4 | THERAPEUTIC AEROSOL FORMULATIONS | — | 1992-04-01 | — | — | EP | disclosed |
| EP-0460064-A1 | THERAPEUTIC AEROSOL FORMULATIONS | RORER INTERNATIONAL (HOLDINGS), INC. (US) | 1991-12-11 | — | — | EP | disclosed |
| WO-1990009781-A1 | THERAPEUTIC AEROSOL FORMULATIONS | RORER INTERNATIONAL (HOLDINGS), INC. (US) | 1990-09-07 | — | — | WO | disclosed |