Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 3/20 | 0.59 |
| ▸ | PPARD | Q03181 | 3/20 | 0.59 |
| ▸ | PPARA | Q07869 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
| ▸ | CYSLTR2 | Q9NS75 | 14/20 | 0.58 |
| ▸ | CYSLTR1 | Q9Y271 | 14/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9620973 | 0.89 | PPARG (0.60) | PPARGPPARDPPARALMNAGRM2 | |
| SCHEMBL4343526 | 0.88 | PPARG (0.67) | PPARGPPARDPPARALMNAGRM2 | |
| SCHEMBL10813934 | 0.87 | CYSLTR2 (0.69) | PPARGPPARDPPARALMNAGRM2 | |
| SCHEMBL6362913 | 0.87 | GRM2 (0.72) | PPARGPPARDPPARALMNAGRM2 | |
| SCHEMBL4915595 | 0.86 | PPARG (0.65) | PPARGPPARDPPARALMNAGRM2 | |
| SCHEMBL10401094 | 0.86 | PPARG (0.65) | PPARGPPARDPPARALMNAGRM2 | |
| SCHEMBL10690212 | 0.85 | GRM2 (0.71) | PPARGPPARDPPARALMNAGRM2 | |
| SCHEMBL11041690 | 0.85 | GRM2 (0.71) | PPARGPPARDPPARALMNAGRM2 | |
| SCHEMBL9381009 | 0.85 | GRM2 (0.71) | PPARGPPARDPPARALMNAGRM2 | |
| SCHEMBL9620518 | 0.84 | CYSLTR2 (0.59) | PPARGPPARDPPARALMNAGRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0232820-B1 | THIOETHERS, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Roche Diagnostics GmbH (DE) | 1992-01-08 | — | — | EP | disclosed |
| US-5025028-A | Asthma | BOEHRINGER MANNHEIM GMBH (DE) | 1991-06-18 | — | — | US | disclosed |
| US-4906666-A | Hydroxamic acids and pharmaceutical compositions containing them, and anti-allergic use thereof | BOEHRINGER MANNHEIM GMBH (DE) | 1990-03-06 | — | — | US | disclosed |
| EP-0232820-A2 | Thioethers, process for their preparation and medicaments containing them | Roche Diagnostics GmbH (DE) | 1987-08-19 | — | — | EP | disclosed |