Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9621703 | 0.82 | ADORA2A (0.44) | SMN1; SMN2KMT2ACYP1A2LMNATSHR | |
| SCHEMBL6242679 | 0.74 | KDM4E (0.56) | SMN1; SMN2KMT2ACYP1A2LMNAADORA2A | |
| SCHEMBL232565 | 0.73 | SMN1; SMN2 (1.00) | SMN1; SMN2KMT2ACYP1A2LMNATSHR | |
| Hydrochloric Acid SCHEMBL11532763 | 0.72 | SMN1; SMN2 (0.97) | SMN1; SMN2KMT2ACYP1A2LMNATSHR | |
| SCHEMBL28385708 | 0.71 | SMN1; SMN2 (0.97) | SMN1; SMN2KMT2ACYP1A2LMNATSHR | |
| SCHEMBL4800021 | 0.68 | ADORA2A (0.48) | SMN1; SMN2KMT2ACYP1A2ADORA2AADORA1 | |
| SCHEMBL15305699 | 0.68 | ADORA2A (0.57) | SMN1; SMN2KMT2ACYP1A2ADORA2AADORA1 | |
| Hydrochloric Acid SCHEMBL4652288 | 0.67 | ADORA2A (0.47) | SMN1; SMN2KMT2ACYP1A2ADORA2AADORA1 | |
| Piperidine SCHEMBL28295718 | 0.67 | SMN1; SMN2 (0.83) | SMN1; SMN2KMT2ACYP1A2LMNATSHR | |
| SCHEMBL23451255 | 0.65 | ADORA2A (0.55) | KMT2ACYP1A2LMNAADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0254158-B1 | PYRIMIDIN DERIVATIVES AND PROCESS FOR THEIR PREPARATION | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1992-01-29 | — | — | EP | disclosed |
| US-4960888-A | Preparation of 6-amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine compounds | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1990-10-02 | — | — | US | disclosed |
| EP-0254158-A2 | Pyrimidin derivatives and process for their preparation | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1988-01-27 | — | — | EP | disclosed |
| EP-0252515-A1 | Process for the preparation of 6-amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidino-pyrimidine | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1988-01-13 | — | — | EP | disclosed |