SCHEMBL9623893

SCHEMBL9623893

COc1cc2c(cc1OC)C(=O)N(CCCN(C)CCc1cccc(C)n1)C2

nearest known ligand 0.46

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HCN4 Q9Y3Q4 2/20 0.46
MAPT P10636 1/20 0.46
CYP3A4 P08684 1/20 0.45
ALOX15 P16050 1/20 0.45
BCHE P06276 1/20 0.42
ACHE P22303 1/20 0.42
DRD3 P35462 3/20 0.39
HTR1A P08908 2/20 0.39
DRD4 P21917 1/20 0.39
HTR4 Q13639 1/20 0.38
ABCB1 P08183 2/20 0.38
SMPD1 P17405 3/20 0.38
DRD2 P14416 1/20 0.37
DRD5 P21918 1/20 0.37
HTR7 P34969 1/20 0.37
CHRM2 P08172 1/20 0.37
SLC6A4 P31645 1/20 0.37
KCNH2 Q12809 1/20 0.37
GNRHR P30968 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9624487 0.90 HCN4 (0.53) HCN4MAPTCYP3A4ALOX15BCHE
SCHEMBL9624933 0.88 HDAC6 (0.38) HCN4MAPTCYP3A4ALOX15DRD3
SCHEMBL9624749 0.81 HCN4 (0.44) HCN4MAPTCYP3A4ALOX15DRD3
Falipamil SCHEMBL30357974 0.81 MAPT (0.68) HCN4MAPTCYP3A4ALOX15DRD3
Falipamil SCHEMBL1817019 0.81 MAPT (0.68) HCN4MAPTCYP3A4ALOX15DRD3
Falipamil SCHEMBL31305297 0.81 MAPT (0.68) HCN4MAPTCYP3A4ALOX15DRD3
SCHEMBL9624286 0.80 HCN4 (0.47) HCN4MAPTCYP3A4ALOX15DRD3
SCHEMBL9624907 0.80 MAPT (0.49) HCN4MAPTCYP3A4ALOX15DRD3
SCHEMBL9624246 0.79 HCN4 (0.46) HCN4MAPTCYP3A4ALOX15DRD3
SCHEMBL9624764 0.79 HCN4 (0.46) HCN4MAPTCYP3A4ALOX15DRD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5116986-A HETEROAROMATIC AMINE DERIVATIVES DR. KARL THOMAE GMBH (DE) 1992-05-26 US disclosed
US-4912115-A Cardiovascular disorders DR. KARL THOMAE GMBH (DE) 1990-03-27 US disclosed
EP-0269968-A2 Heteroaromatic amine derivatives, medicaments containing them and process for their preparation Dr. Karl Thomae GmbH (DE) 1988-06-08 EP disclosed