Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.51 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.51 |
| ▸ | DRD3 | P35462 | 2/20 | 0.51 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.51 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.51 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.51 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.51 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9624530 | 0.95 | KDM4E (0.58) | KDM4EHPGDLMNAALDH1A1HTT | |
| SCHEMBL10528894 | 0.93 | KCNH2 (0.57) | KDM4EHPGDLMNAALDH1A1HTT | |
| SCHEMBL9625821 | 0.89 | KCNH2 (0.66) | KDM4EHPGDLMNAALDH1A1HTT | |
| SCHEMBL3336139 | 0.87 | KDM4E (0.73) | KDM4EHPGDLMNAALDH1A1HTT | |
| SCHEMBL9624804 | 0.86 | KCNH2 (0.66) | KDM4EHPGDLMNAALDH1A1HTT | |
| Methane SCHEMBL10642438 | 0.85 | HPGD (0.55) | KDM4EHPGDLMNASMN1; SMN2FFAR1 | |
| Hydrochloric Acid SCHEMBL10529761 | 0.85 | KCNH2 (0.65) | KDM4EHPGDLMNAALDH1A1HTT | |
| Bromide SCHEMBL10529006 | 0.85 | KCNH2 (0.65) | KDM4EHPGDLMNAALDH1A1HTT | |
| SCHEMBL16976564 | 0.84 | KDM4E (0.65) | KDM4EHPGDLMNAALDH1A1HTT | |
| SCHEMBL8014658 | 0.83 | KCNH2 (0.67) | KCNH2GRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0164865-B1 | N-(AMINOALKYLPHENYL)SULFONAMIDES THEIR PREPARATION AND THERAPEUTIC USE | THE UPJOHN COMPANY (US) | 1988-12-21 | — | — | EP | claimed |
| EP-0164865-A1 | N-(Aminoalkylphenyl)sulfonamides their preparation and therapeutic use | THE UPJOHN COMPANY (US) | 1985-12-18 | — | — | EP | claimed |
| US-5155268-A | Antiarrhythmic N-aminoalkylene alkyl and aryl sulfonamides | THE UPJOHN COMPANY (US) | 1992-10-13 | — | — | US | disclosed |