SCHEMBL9625372

SCHEMBL9625372

CCCc1ccc(-c2ccc(C=C(F)F)cc2)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RARB P10826 6/20 0.42
MCL1 Q07820 1/20 0.41
LPL P06858 1/20 0.41
LIPG Q9Y5X9 1/20 0.41
THRB P10828 2/20 0.40
ALDH1A1 P00352 3/20 0.38
KDM4E B2RXH2 1/20 0.38
MITF O75030 1/20 0.38
HPGD P15428 1/20 0.38
KLF5 Q13887 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
GRIN2D O15399 1/20 0.37
GRIN3B O60391 1/20 0.37
GRIN1 Q05586 1/20 0.37
GRIN2A Q12879 1/20 0.37
GRIN2B Q13224 1/20 0.37
GRIN2C Q14957 1/20 0.37
GRIN3A Q8TCU5 1/20 0.37
PLK1 P53350 1/20 0.37
MAPT P10636 3/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9625356 0.91 RARB (0.53) RARBTHRBALDH1A1KDM4EHPGD
SCHEMBL9625465 0.88 RARB (0.53) RARBLPLLIPGALDH1A1KDM4E
SCHEMBL7236319 0.87 MCL1 (0.41) RARBMCL1LPLLIPGTHRB
SCHEMBL7236324 0.87 MCL1 (0.41) RARBMCL1LPLLIPGTHRB
SCHEMBL9624393 0.86 RARB (0.54) RARBLPLLIPGTHRBALDH1A1
SCHEMBL9626444 0.86 RARB (0.54) RARBLPLLIPGTHRBALDH1A1
SCHEMBL9625305 0.86 RARB (0.54) RARBLPLLIPGTHRBALDH1A1
SCHEMBL9626052 0.86 RARB (0.54) RARBLPLLIPGTHRBALDH1A1
SCHEMBL9625201 0.86 RARB (0.54) RARBLPLLIPGTHRBALDH1A1
SCHEMBL9625979 0.86 RARB (0.54) RARBLPLLIPGTHRBALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0325796-B1 A LIQUID CRYSTAL COMPOUND AND A MIXTURE CONTAINING THE SAME Chisso Corporation (JP) 1992-03-11 EP disclosed
US-4877548-A STABLE TO HEAT, LIGHT, ELECTRICITY AND MOISTURE CHISSO CORPORATION (JP) 1989-10-31 US disclosed
EP-0325796-A1 A liquid crystal compound and a mixture containing the same Chisso Corporation (JP) 1989-08-02 EP disclosed