Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 1.00 |
| ▸ | CACNA1F | O60840 | 1/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 1/20 | 1.00 |
| ▸ | ADRA2B | P18089 | 1/20 | 1.00 |
| ▸ | ADRA2C | P18825 | 1/20 | 1.00 |
| ▸ | CHRM3 | P20309 | 1/20 | 1.00 |
| ▸ | HTR2A | P28223 | 1/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 1/20 | 1.00 |
| ▸ | DRD3 | P35462 | 1/20 | 1.00 |
| ▸ | CACNA1D | Q01668 | 1/20 | 1.00 |
| ▸ | CACNA1S | Q13698 | 1/20 | 1.00 |
| ▸ | CACNA1C | Q13936 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.49 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ibutilide SCHEMBL3719856 | 1.00 | KCNH2 (1.00) | KCNH2CACNA1FCHRM2ADRA2BADRA2C | |
| Ibutilide SCHEMBL16373 | 1.00 | KCNH2 (1.00) | KCNH2CACNA1FCHRM2ADRA2BADRA2C | |
| Ibutilide SCHEMBL29761428 | 1.00 | KCNH2 (1.00) | KCNH2CACNA1FCHRM2ADRA2BADRA2C | |
| SCHEMBL9624685 | 0.99 | KCNH2 (0.98) | KCNH2CACNA1FCHRM2ADRA2BADRA2C | |
| SCHEMBL9226333 | 0.96 | KCNH2 (0.93) | KCNH2CACNA1FCHRM2ADRA2BADRA2C | |
| SCHEMBL15741320 | 0.93 | KCNH2 (0.86) | KCNH2CACNA1FCHRM2ADRA2BADRA2C | |
| Ibutilide SCHEMBL1649397 | 0.92 | KCNH2 (0.85) | KCNH2CACNA1FCHRM2ADRA2BADRA2C | |
| Ibutilide SCHEMBL15540420 | 0.92 | KCNH2 (0.85) | KCNH2CACNA1FCHRM2ADRA2BADRA2C | |
| Ibutilide SCHEMBL42073 | 0.92 | KCNH2 (0.85) | KCNH2CACNA1FCHRM2ADRA2BADRA2C | |
| Ibutilide SCHEMBL42074 | 0.92 | KCNH2 (0.85) | KCNH2CACNA1FCHRM2ADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0164865-B1 | N-(AMINOALKYLPHENYL)SULFONAMIDES THEIR PREPARATION AND THERAPEUTIC USE | THE UPJOHN COMPANY (US) | 1988-12-21 | — | — | EP | claimed |
| EP-0164865-A1 | N-(Aminoalkylphenyl)sulfonamides their preparation and therapeutic use | THE UPJOHN COMPANY (US) | 1985-12-18 | — | — | EP | claimed |
| US-5155268-A | Antiarrhythmic N-aminoalkylene alkyl and aryl sulfonamides | THE UPJOHN COMPANY (US) | 1992-10-13 | — | — | US | disclosed |
| EP-0164865-B1 | N-(AMINOALKYLPHENYL)SULFONAMIDES THEIR PREPARATION AND THERAPEUTIC USE | THE UPJOHN COMPANY (US) | 1988-12-21 | — | — | EP | disclosed |
| EP-0164865-A1 | N-(Aminoalkylphenyl)sulfonamides their preparation and therapeutic use | THE UPJOHN COMPANY (US) | 1985-12-18 | — | — | EP | disclosed |