Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.76 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.76 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.76 |
| ▸ | ACHE | P22303 | 1/20 | 0.76 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.76 |
| ▸ | DRD3 | P35462 | 1/20 | 0.76 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.76 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.76 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.76 |
| ▸ | HPGD | P15428 | 4/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9826819 | 0.92 | KCNH2 (0.67) | KCNH2CACNA1FCHRM2ACHEAGTR1 | |
| SCHEMBL9080508 | 0.89 | CACNA1F (0.62) | KCNH2CACNA1FCHRM2ACHEAGTR1 | |
| Dofetilide SCHEMBL16135 | 0.87 | KCNH2 (1.00) | KCNH2CACNA1FCHRM2ACHEAGTR1 | |
| SCHEMBL9628884 | 0.87 | KCNH2 (0.64) | KCNH2CACNA1FCHRM2ACHEAGTR1 | |
| Dofetilide SCHEMBL6102734 | 0.87 | KCNH2 (1.00) | KCNH2CACNA1FCHRM2ACHEAGTR1 | |
| SCHEMBL9080505 | 0.86 | KCNH2 (0.59) | KCNH2CACNA1FCHRM2ACHEAGTR1 | |
| SCHEMBL9384829 | 0.86 | KCNH2 (0.60) | KCNH2CACNA1FCHRM2ACHEAGTR1 | |
| Dofetilide SCHEMBL8362214 | 0.86 | KCNH2 (0.97) | KCNH2CACNA1FCHRM2ACHEAGTR1 | |
| SCHEMBL8781733 | 0.85 | KCNH2 (0.72) | KCNH2CACNA1FCHRM2ACHEAGTR1 | |
| SCHEMBL9826588 | 0.84 | CACNA1F (0.57) | KCNH2CACNA1FCHRM2ACHEAGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0245997-B1 | N-SUBSTITUTED P-AMINOETHYLSULPHON ANILIDES AS ANTIARRHYTHMIC AGENTS, AND INTERMEDIATES THEREFOR | Pfizer Limited (GB) | 1992-04-15 | — | — | EP | disclosed |
| US-5079248-A | Antifibrillatory agents; side effect reduction | PFIZER INC. (US) | 1992-01-07 | — | — | US | disclosed |
| US-4959366-A | Anti-arrhythmic agents | PFIZER INC. (US) | 1990-09-25 | — | — | US | disclosed |
| EP-0245997-A2 | N-substituted p-aminoethylsulphon anilides as antiarrhythmic agents, and intermediates therefor | Pfizer Limited (GB) | 1987-11-19 | — | — | EP | disclosed |