Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 16/20 | 0.80 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.80 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.80 |
| ▸ | ACHE | P22303 | 1/20 | 0.80 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.80 |
| ▸ | DRD3 | P35462 | 1/20 | 0.80 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.80 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.80 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.80 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9630209 | 1.00 | KCNH2 (0.80) | KCNH2CACNA1FCHRM2ACHEAGTR1 | |
| Dofetilide SCHEMBL6102734 | 0.90 | KCNH2 (1.00) | KCNH2CACNA1FCHRM2ACHEAGTR1 | |
| Dofetilide SCHEMBL16135 | 0.90 | KCNH2 (1.00) | KCNH2CACNA1FCHRM2ACHEAGTR1 | |
| Dofetilide SCHEMBL8362214 | 0.89 | KCNH2 (0.97) | KCNH2CACNA1FCHRM2ACHEAGTR1 | |
| SCHEMBL3929250 | 0.87 | KCNH2 (1.00) | KCNH2CACNA1FCHRM2ACHEAGTR1 | |
| SCHEMBL24600680 | 0.84 | KCNH2 (0.88) | KCNH2CACNA1FCHRM2ACHEAGTR1 | |
| SCHEMBL26239229 | 0.84 | KCNH2 (0.88) | KCNH2CACNA1FCHRM2ACHEAGTR1 | |
| SCHEMBL9628071 | 0.84 | KCNH2 (0.88) | KCNH2CACNA1FCHRM2ACHEAGTR1 | |
| SCHEMBL9628293 | 0.84 | KCNH2 (0.88) | KCNH2CACNA1FCHRM2ACHEAGTR1 | |
| SCHEMBL13480196 | 0.83 | KCNH2 (0.80) | KCNH2CACNA1FCHRM2ACHEAGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108164429-B | Preparation method of dofetilide intermediate | 四川科瑞德凯华制药有限公司 | 2021-07-23 | — | — | CN | disclosed |
| CN-108164429-A | The preparation method of Dofetilide intermediate | 四川科瑞德凯华制药有限公司 | 2018-06-15 | — | — | CN | disclosed |
| EP-0245997-B1 | N-SUBSTITUTED P-AMINOETHYLSULPHON ANILIDES AS ANTIARRHYTHMIC AGENTS, AND INTERMEDIATES THEREFOR | Pfizer Limited (GB) | 1992-04-15 | — | — | EP | disclosed |
| US-5079248-A | Antifibrillatory agents; side effect reduction | PFIZER INC. (US) | 1992-01-07 | — | — | US | disclosed |
| US-4959366-A | Anti-arrhythmic agents | PFIZER INC. (US) | 1990-09-25 | — | — | US | disclosed |
| EP-0245997-A2 | N-substituted p-aminoethylsulphon anilides as antiarrhythmic agents, and intermediates therefor | Pfizer Limited (GB) | 1987-11-19 | — | — | EP | disclosed |