Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.47 |
| ▸ | HTR2C | P28335 | 3/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | DRD3 | P35462 | 2/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.47 |
| ▸ | HRH1 | P35367 | 2/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | HRH2 | P25021 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1178078 | 1.00 | SLC6A2 (0.52) | SLC6A2SLC6A3CHRM2CHRM5CHRM1 | |
| SCHEMBL1178075 | 1.00 | SLC6A2 (0.52) | SLC6A2SLC6A3CHRM2CHRM5CHRM1 | |
| Fumaric Acid SCHEMBL1177745 | 0.90 | SLC6A2 (0.46) | SLC6A2SLC6A3CHRM2CHRM5CHRM1 | |
| SCHEMBL1177925 | 0.79 | SLC6A2 (0.59) | SLC6A2SLC6A3CHRM2CHRM5CHRM1 | |
| SCHEMBL1177498 | 0.79 | SLC6A2 (0.59) | SLC6A2SLC6A3CHRM2CHRM5CHRM1 | |
| SCHEMBL5469724 | 0.74 | ROCK1 (0.49) | SLC6A2SLC6A3CHRM3HTR2CHRH1 | |
| Hydrochloric Acid SCHEMBL5476262 | 0.73 | ROCK1 (0.48) | SLC6A2CHRM3HTR2CHRH1HCRTR1 | |
| SCHEMBL29586291 | 0.73 | HCRTR1 (0.47) | HCRTR1HCRTR2MAPT | |
| SCHEMBL21047726 | 0.73 | HCRTR1 (0.47) | HCRTR1HCRTR2MAPT | |
| Hydrochloric Acid SCHEMBL29862550 | 0.73 | ROCK1 (0.48) | SLC6A2CHRM3HTR2CHRH1HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5082843-A | PYRAZINYL AND PYRIDAZINYL ETHERS | JOHN WYETH AND BROTHER LIMITED (GB) | 1992-01-21 | — | — | US | disclosed |
| US-4929625-A | Ethers | JOHN WYETH AND BROTHERS LIMITED (GB) | 1990-05-29 | — | — | US | disclosed |