Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11694294 | 0.95 | CRBN (0.39) | CRBNPOLBALDH1A1 | |
| SCHEMBL3077327 | 0.78 | — | — | |
| SCHEMBL28946959 | 0.78 | — | — | |
| SCHEMBL3074488 | 0.76 | CRBN (0.36) | CRBNPOLB | |
| SCHEMBL3070676 | 0.70 | — | — | |
| SCHEMBL3078358 | 0.68 | CRBN (0.39) | CRBNPOLBALDH1A1 | |
| SCHEMBL3057701 | 0.68 | CRBN (0.39) | CRBNPOLBALDH1A1 | |
| SCHEMBL653996 | 0.68 | CRBN (0.53) | CRBNPOLBALDH1A1 | |
| SCHEMBL11865967 | 0.66 | EPHX1 (0.41) | POLB | |
| SCHEMBL9349323 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0357192-B1 | PROCESS FOR PREPARING SUBSTITUTED GUANYLTHIOUREAS | PFIZER INC. (US) | 1992-05-06 | — | — | EP | disclosed |
| EP-0357192-A1 | Process for preparing substituted guanylthioureas | PFIZER INC. (US) | 1990-03-07 | — | — | EP | disclosed |