Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 8/20 | 0.49 |
| ▸ | AMY1A | P0DUB6 | 5/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9634658 | 0.92 | PDE5A (0.52) | PDE5AAMY1AAURKAPDE3BPDE3A | |
| SCHEMBL9634411 | 0.91 | PDE5A (0.44) | PDE5AAMY1AMAOBKDM4EALDH1A1 | |
| SCHEMBL9634920 | 0.88 | PDE5A (0.44) | PDE5AAMY1AKDM4EALDH1A1NPC1 | |
| SCHEMBL10737722 | 0.87 | PDE5A (0.43) | PDE5AAMY1AAURKAMAOBFGFR1 | |
| SCHEMBL9635443 | 0.87 | PDE5A (0.53) | PDE5AMAOBKDM4EALDH1A1 | |
| SCHEMBL7278363 | 0.85 | PDE5A (0.62) | PDE5AAMY1AAURKAPDE3BPDE3A | |
| SCHEMBL9635975 | 0.85 | PDE5A (0.46) | PDE5AAMY1AAURKAPDE3BPDE3A | |
| Hydrochloric Acid SCHEMBL10416659 | 0.84 | PDE5A (0.63) | PDE5AAMY1AAURKAPDE3BPDE3A | |
| SCHEMBL11011131 | 0.83 | MAOB (0.39) | PDE5AAMY1AMAOBALDH1A1FGFR1 | |
| SCHEMBL9634736 | 0.81 | PDE2A (0.47) | PDE5AAMY1AAURKAPDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5104881-A | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-04-14 | — | — | US | disclosed |
| US-4616090-A | 2-arylimidazopyridines intermediates | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1986-10-07 | — | — | US | disclosed |
| EP-0072926-B1 | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GmbH (DE) | 1986-09-24 | — | — | EP | disclosed |
| EP-0072926-A1 | 2-Arylimidazopyridines | MERCK PATENT GmbH (DE) | 1983-03-02 | — | — | EP | disclosed |