Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 14/20 | 0.71 |
| ▸ | CYP11B2 | P19099 | 8/20 | 0.66 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.66 |
| ▸ | MIF | P14174 | 2/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.66 |
| ▸ | PKM | P14618 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | TNF | P01375 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
| ▸ | XBP1 | P17861 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4222681 | 0.88 | CYP19A1 (0.78) | CYP19A1CYP11B2CYP11B1MIFMAPK1 | |
| SCHEMBL4222678 | 0.88 | CYP19A1 (0.78) | CYP19A1CYP11B2CYP11B1MIFMAPK1 | |
| SCHEMBL4222684 | 0.88 | CYP19A1 (0.78) | CYP19A1CYP11B2CYP11B1MIFMAPK1 | |
| SCHEMBL29228580 | 0.81 | CYP19A1 (0.49) | CYP19A1CYP11B2CYP11B1MIFMAPK1 | |
| SCHEMBL29228575 | 0.81 | CYP19A1 (0.49) | CYP19A1CYP11B2CYP11B1MIFMAPK1 | |
| SCHEMBL6827818 | 0.80 | CYP19A1 (1.00) | CYP19A1CYP11B2MIFMAPK1PKM | |
| SCHEMBL6827821 | 0.80 | CYP19A1 (1.00) | CYP19A1CYP11B2MIFMAPK1PKM | |
| SCHEMBL4231428 | 0.80 | CYP19A1 (0.65) | CYP19A1CYP11B2CYP11B1MAPK1MAPT | |
| SCHEMBL4231435 | 0.80 | CYP19A1 (0.65) | CYP19A1CYP11B2CYP11B1MAPK1MAPT | |
| SCHEMBL4231430 | 0.80 | CYP19A1 (0.65) | CYP19A1CYP11B2CYP11B1MAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5114949-A | Treating disorders associated with 5HT uptake | RHONE-POULENC SANTE (FR) | 1992-05-19 | — | — | US | disclosed |