Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | PORCN | Q9H237 | 2/20 | 0.50 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.45 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9635682 | 0.99 | HTT (0.61) | HTTPORCNATAD2CECR2TSHR | |
| SCHEMBL11512524 | 0.86 | HTT (0.82) | HTTPORCNATAD2CECR2TSHR | |
| SCHEMBL11110025 | 0.77 | TSHR (0.63) | HTTATAD2CECR2TSHRLMNA | |
| SCHEMBL11105997 | 0.77 | TSHR (0.63) | HTTATAD2CECR2TSHRLMNA | |
| SCHEMBL11112926 | 0.77 | TSHR (0.63) | HTTATAD2CECR2TSHRLMNA | |
| SCHEMBL11512586 | 0.76 | KMT2A (0.54) | HTTATAD2CECR2TSHRLMNA | |
| SCHEMBL11391291 | 0.76 | HTT (1.00) | HTTPORCNATAD2CECR2TSHR | |
| SCHEMBL9206004 | 0.75 | HTT (0.59) | HTTATAD2CECR2TSHRLMNA | |
| SCHEMBL11110283 | 0.75 | HTT (0.49) | HTTATAD2CECR2TSHRLMNA | |
| SCHEMBL11110801 | 0.75 | HTT (0.49) | HTTATAD2CECR2TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0308337-B1 | 4-AMINOPYRIDINE DERIVATIVES AND THEIR ACID ADDITION SALTS | MITSUBISHI KASEI CORPORATION (JP) | 1992-06-17 | — | — | EP | disclosed |
| US-4880819-A | ALZHEIMER*S DISEASE, PEPTIDE DERIVATIVE | MITSUBISHI KASEI CORPORATION (JP) | 1989-11-14 | — | — | US | disclosed |
| EP-0308337-A2 | 4-Aminopyridine derivatives and their acid addition salts | MITSUBISHI KASEI CORPORATION (JP) | 1989-03-22 | — | — | EP | disclosed |