Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.47 |
| ▸ | PDE5A | O76074 | 7/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | AMY1A | P0DUB6 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | CBFB | Q13951 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9636138 | 0.92 | PDE5A (0.46) | PDE2APDE5ACYP11B1CYP11B2PDE3B | |
| SCHEMBL9634798 | 0.90 | PDE5A (0.47) | PDE5ACYP11B1CYP11B2PDE3BPDE3A | |
| SCHEMBL7282319 | 0.90 | PDE5A (0.54) | PDE2APDE5ACYP11B1CYP11B2PDE3B | |
| SCHEMBL7271240 | 0.90 | PDE2A (0.48) | PDE2APDE5ACYP11B1CYP11B2PDE3B | |
| SCHEMBL7279538 | 0.90 | PDE5A (0.51) | PDE2APDE5ACYP11B1CYP11B2PDE3B | |
| SCHEMBL10416990 | 0.89 | PDE2A (0.47) | PDE2APDE5ACYP11B1CYP11B2PDE3B | |
| Hydrochloric Acid SCHEMBL10849048 | 0.89 | PDE5A (0.51) | PDE2APDE5ACYP11B1CYP11B2PDE3B | |
| SCHEMBL10848217 | 0.89 | PDE2A (0.47) | PDE2APDE5ACYP11B1CYP11B2PDE3B | |
| SCHEMBL9634828 | 0.88 | PDE5A (0.45) | PDE2APDE5APDE3BPDE3AKDM4E | |
| SCHEMBL7272286 | 0.88 | PDE2A (0.50) | PDE2APDE5ACYP11B1CYP11B2PDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5104881-A | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-04-14 | — | — | US | disclosed |
| US-4616090-A | 2-arylimidazopyridines intermediates | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1986-10-07 | — | — | US | disclosed |
| EP-0072926-B1 | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GmbH (DE) | 1986-09-24 | — | — | EP | disclosed |
| EP-0072926-A1 | 2-Arylimidazopyridines | MERCK PATENT GmbH (DE) | 1983-03-02 | — | — | EP | disclosed |