Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | TOP1 | P11387 | 1/20 | 0.40 |
| ▸ | TOP2A | P11388 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 3/20 | 0.40 |
| ▸ | MAOA | P21397 | 2/20 | 0.40 |
| ▸ | AMY1A | P0DUB6 | 4/20 | 0.39 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | MELK | Q14680 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9634342 | 0.92 | PDE5A (0.41) | PDE5AKDM4EALDH1A1HPGDPDE3B | |
| SCHEMBL9634540 | 0.92 | PDE5A (0.47) | PDE5AKDM4EALDH1A1HPGDPDE3B | |
| SCHEMBL10962083 | 0.91 | PDE5A (0.42) | PDE5AKDM4EALDH1A1HPGDPDE3B | |
| SCHEMBL9636217 | 0.91 | MAOB (0.41) | PDE5AKDM4EALDH1A1HPGDTOP1 | |
| SCHEMBL10740337 | 0.87 | TOP1 (0.41) | PDE5AKDM4EALDH1A1HPGDPDE3B | |
| SCHEMBL9634591 | 0.86 | TOP1 (0.40) | PDE5APDE3BPDE3ATOP1TOP2A | |
| SCHEMBL7281035 | 0.85 | PDE5A (0.55) | PDE5AKDM4EALDH1A1HPGDPDE3B | |
| SCHEMBL9634736 | 0.85 | PDE2A (0.47) | PDE5AKDM4EALDH1A1HPGDPDE3B | |
| SCHEMBL9634582 | 0.84 | PDE5A (0.40) | PDE5AKDM4EALDH1A1HPGDPDE3B | |
| Hydrochloric Acid SCHEMBL10844959 | 0.84 | PDE5A (0.56) | PDE5AKDM4EALDH1A1HPGDPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5104881-A | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-04-14 | — | — | US | disclosed |
| US-4616090-A | 2-arylimidazopyridines intermediates | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1986-10-07 | — | — | US | disclosed |
| EP-0072926-B1 | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GmbH (DE) | 1986-09-24 | — | — | EP | disclosed |
| EP-0072926-A1 | 2-Arylimidazopyridines | MERCK PATENT GmbH (DE) | 1983-03-02 | — | — | EP | disclosed |