Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 10/20 | 0.54 |
| ▸ | CYSLTR2 | Q9NS75 | 4/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.44 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9635446 | 0.91 | CYSLTR1 (0.60) | CYSLTR1CYSLTR2ALOX5GPBAR1 | |
| SCHEMBL9635476 | 0.85 | CYSLTR1 (0.54) | CYSLTR1CYSLTR2ALOX5GPBAR1 | |
| SCHEMBL9673021 | 0.85 | CYSLTR1 (0.53) | CYSLTR1CYSLTR2ALOX5GPBAR1 | |
| SCHEMBL9635485 | 0.85 | CYSLTR1 (0.55) | CYSLTR1CYSLTR2ALOX5GPBAR1 | |
| SCHEMBL9674403 | 0.84 | CYSLTR1 (0.52) | CYSLTR1CYSLTR2ALOX5 | |
| SCHEMBL9635480 | 0.82 | CYSLTR1 (0.60) | CYSLTR1CYSLTR2ALOX5GPBAR1 | |
| SCHEMBL9635519 | 0.80 | CYSLTR1 (0.75) | CYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL9635502 | 0.79 | AKR1B1 (0.53) | CYSLTR1CYSLTR2ALOX5GPBAR1 | |
| SCHEMBL6089067 | 0.77 | CYSLTR1 (0.60) | CYSLTR1CYSLTR2ALOX5GPBAR1 | |
| SCHEMBL6175634 | 0.77 | CYSLTR1 (0.79) | CYSLTR1CYSLTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5082849-A | Antiinflammatory agents or antiallergens | AVENTIS PHARMACEUTICALS INC. | 1992-01-21 | — | — | US | disclosed |
| EP-0434827-A4 | QUINOLINYL-BENZOPYRAN DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D 4? | — | 1992-01-08 | — | — | EP | disclosed |
| EP-0434827-A1 | QUINOLINYL-BENZOPYRAN DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D 4? | RORER INTERNATIONAL (HOLDINGS), INC. (US) | 1991-07-03 | — | — | EP | disclosed |
| WO-1991001123-A2 | QUINOLINYL-BENZOPYRAN DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D¿4? | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1991-02-07 | — | — | WO | disclosed |
| US-4977162-A | Quinolinyl-chromone derivatives and use for treatment of hypersensitive ailments | RORER PHARMACEUTICAL CORPORATION (US) | 1990-12-11 | — | — | US | disclosed |