Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 17/20 | 0.59 |
| ▸ | CYSLTR1 | Q9Y271 | 17/20 | 0.59 |
| ▸ | CTSD | P07339 | 1/20 | 0.52 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | PPARD | Q03181 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9638098 | 0.86 | CYSLTR2 (0.54) | CYSLTR2CYSLTR1CTSDGRM2 | |
| SCHEMBL9175712 | 0.85 | CYSLTR2 (0.64) | CYSLTR2CYSLTR1CTSDGRM2LMNA | |
| SCHEMBL9177346 | 0.85 | CYSLTR2 (0.63) | CYSLTR2CYSLTR1CTSD | |
| SCHEMBL9173547 | 0.84 | GRM2 (0.68) | CYSLTR2CYSLTR1CTSDGRM2LMNA | |
| SCHEMBL9177294 | 0.84 | CYSLTR2 (0.63) | CYSLTR2CYSLTR1CTSD | |
| SCHEMBL9638148 | 0.84 | CYSLTR2 (0.60) | CYSLTR2CYSLTR1CTSDGRM2LMNA | |
| SCHEMBL9638144 | 0.82 | CYSLTR2 (0.58) | CYSLTR2CYSLTR1CTSDGRM2LMNA | |
| SCHEMBL9637077 | 0.82 | CYSLTR2 (0.58) | CYSLTR2CYSLTR1CTSDGRM2LMNA | |
| SCHEMBL9176134 | 0.82 | CYSLTR2 (0.57) | CYSLTR2CYSLTR1CTSD | |
| SCHEMBL9179128 | 0.81 | CYSLTR2 (0.62) | CYSLTR2CYSLTR1CTSDGRM2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0288190-B1 | IMPROVEMENTS IN OR RELATING TO LEUKOTRIENE ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1992-07-08 | — | — | EP | disclosed |
| US-4874777-A | ANTIASTHMATICS | ELI LILLY AND COMPANY (US) | 1989-10-17 | — | — | US | disclosed |
| EP-0288190-A1 | Improvements in or relating to leukotriene antagonists | ELI LILLY AND COMPANY (US) | 1988-10-26 | — | — | EP | disclosed |