SCHEMBL9637767

SCHEMBL9637767

C=CC(=O)OC(C)[Si](C)(C)C

nearest known ligand 0.43

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
TSHR P16473 8/20 0.43
HPGD P15428 1/20 0.33
ALDH1A1 P00352 4/20 0.32
TP53 P04637 2/20 0.32
HIF1A Q16665 2/20 0.32
CYP3A4 P08684 1/20 0.32
HSD17B10 Q99714 1/20 0.32
HCAR2 Q8TDS4 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7267949 0.84 TSHR (0.40) TSHRHPGDALDH1A1TP53HIF1A
SCHEMBL28555596 0.83 TSHR (0.41) TSHRHPGDALDH1A1TP53HIF1A
SCHEMBL16537252 0.81 TSHR (0.39) TSHRHPGD
SCHEMBL1066969 0.81 TSHR (0.39) TSHRHPGD
SCHEMBL28024178 0.79 TSHR (0.38) TSHRHPGDALDH1A1TP53HIF1A
SCHEMBL11177532 0.79 HCAR2 (0.32) HCAR2
SCHEMBL1200031 0.78 TSHR (0.41) TSHRHPGDALDH1A1TP53HIF1A
Water SCHEMBL11033305 0.77 HCAR2 (0.31) HCAR2
SCHEMBL16536505 0.77 TSHR (0.40) TSHRHPGDALDH1A1TP53HIF1A
SCHEMBL1066178 0.77 TSHR (0.40) TSHRHPGDALDH1A1TP53HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0273457-B1 ANTIFOULING PAINT NIPPON OIL AND FATS COMPANY, LIMITED (JP) 1992-07-08 EP disclosed
US-4898895-A Antifouling pain having a polyacrylate component with pendent silyl or siloxane groups NIPPON OIL AND FATS CO., LTD. (JP) 1990-02-06 US disclosed
US-4883852-A SILICON CONTAINING ACRYLIC ESTER POLYMER, POLYSILOXANES NIPPON OIL AND FATS CO., LTD. (JP) 1989-11-28 US disclosed
EP-0273457-A2 Antifouling paint NIPPON OIL AND FATS COMPANY, LIMITED (JP) 1988-07-06 EP disclosed