Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.66 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.58 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.58 |
| ▸ | RORC | P51449 | 3/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 6/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9638365 | 1.00 | KCNH2 (0.66) | KCNH2PDE3BPDE3ARORCS1PR1 | |
| SCHEMBL9638791 | 0.94 | KCNH2 (0.62) | KCNH2PDE3BPDE3ARORCS1PR1 | |
| SCHEMBL9638784 | 0.94 | KCNH2 (0.62) | KCNH2PDE3BPDE3ARORCS1PR1 | |
| SCHEMBL9639036 | 0.90 | KCNH2 (0.75) | KCNH2PDE3BPDE3ARORCS1PR1 | |
| SCHEMBL9639040 | 0.90 | KCNH2 (0.75) | KCNH2PDE3BPDE3ARORCS1PR1 | |
| SCHEMBL9638715 | 0.88 | KCNH2 (0.84) | KCNH2PDE3BPDE3ARORCGPR119 | |
| SCHEMBL9638719 | 0.88 | KCNH2 (0.84) | KCNH2PDE3BPDE3ARORCGPR119 | |
| SCHEMBL9639427 | 0.87 | KCNH2 (0.70) | KCNH2PDE3BPDE3ARORCGPR119 | |
| SCHEMBL9639424 | 0.87 | KCNH2 (0.70) | KCNH2PDE3BPDE3ARORCGPR119 | |
| SCHEMBL9638250 | 0.86 | KCNH2 (0.70) | KCNH2PDE3BPDE3ARORCGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5137885-A | THIADIAZINONES | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 1992-08-11 | — | — | US | disclosed |
| EP-0492257-A1 | Thiadiazinone derivatives | MERCK PATENT GmbH (DE) | 1992-07-01 | — | — | EP | disclosed |