SCHEMBL9643244

SCHEMBL9643244

COC1=C(OC)C(=O)c2c(Sc3ccccc3Br)cccc2C1=O

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 9/20 0.49
ALDH1A1 P00352 7/20 0.49
SMN1; SMN2 Q16637 5/20 0.49
RAB9A P51151 5/20 0.49
LMNA P02545 4/20 0.49
KDM4E B2RXH2 3/20 0.49
POLB P06746 3/20 0.49
CDC25A P30304 2/20 0.49
CDC25B P30305 2/20 0.49
TDP1 Q9NUW8 2/20 0.49
HPGD P15428 2/20 0.49
MAP2K7 O14733 1/20 0.49
GMNN O75496 1/20 0.49
TP53 P04637 1/20 0.49
CYP1A2 P05177 1/20 0.49
CYP3A4 P08684 1/20 0.49
CYP2D6 P10635 1/20 0.49
CYP2C9 P11712 1/20 0.49
ALOX15 P16050 1/20 0.49
CYP2C19 P33261 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11142654 0.82 MAPT (0.49) MAPTALDH1A1SMN1; SMN2RAB9ALMNA
SCHEMBL9641819 0.82 MAPT (0.71) MAPTALDH1A1SMN1; SMN2RAB9ALMNA
SCHEMBL11140562 0.81 MAPT (0.47) MAPTALDH1A1SMN1; SMN2RAB9ALMNA
SCHEMBL11139498 0.81 KDM4E (0.53) MAPTALDH1A1SMN1; SMN2RAB9ALMNA
SCHEMBL9713755 0.81 IDO1 (0.51) MAPTALDH1A1LMNAKDM4ECDC25A
SCHEMBL9643376 0.78 MAPT (0.53) MAPTALDH1A1SMN1; SMN2RAB9ALMNA
SCHEMBL11139595 0.77 KDM4E (0.54) MAPTALDH1A1SMN1; SMN2RAB9ALMNA
SCHEMBL9642998 0.77 KDM4E (0.44) MAPTALDH1A1SMN1; SMN2RAB9ALMNA
SCHEMBL11141348 0.76 MAPT (0.45) MAPTALDH1A1SMN1; SMN2RAB9ALMNA
SCHEMBL11142278 0.75 MAPT (0.53) MAPTALDH1A1SMN1; SMN2RAB9ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0215622-B1 NAPHTHALENE ANTI-PSORIATIC AGENTS AND PROCESS FOR MAKING THEM SYNTEX (U.S.A.) INC. (US) 1992-06-17 EP disclosed
US-4946845-A STABLE ANTIINFLAMMATORY AGENTS, LIPOXYGENASE INHIBITORS SYNTEX (U.S.A.) INC. (US) 1990-08-07 US disclosed
EP-0146145-B1 NAPHTHALENE ANTI-PSORIATIC AGENTS SYNTEX (U.S.A.) INC. (US) 1989-08-30 EP disclosed
US-4792556-A LIPOXYGENASE INHIBITORS SYNTEX (U.S.A.) INC. (US) 1988-12-20 US disclosed
EP-0215622-A2 Naphthalene anti-psoriatic agents and process for making them SYNTEX (U.S.A.) INC. (US) 1987-03-25 EP disclosed
US-4593120-A Naphthalene-1,4-dicarboxylic acid group SYNTEX (U.S.A.) INC. (US) 1986-06-03 US disclosed
EP-0107512-B1 1,4-ACYLOXYNAPHTHALENE DERIVATIVES, TOPICAL COMPOSITIONS CONTAINING THEM, METHODS FOR THEIR PREPARATION, AND INTERMEDIATES THEREFOR SYNTEX (U.S.A.) INC. (US) 1986-02-26 EP disclosed
EP-0146145-A2 Naphthalene anti-psoriatic agents SYNTEX (U.S.A.) INC. (US) 1985-06-26 EP disclosed
US-4466981-A Naphthalene anti-psoriatic agents SYNTEX (U.S.A.) INC. (US) 1984-08-21 US disclosed
EP-0107512-A1 1,4-Acyloxynaphthalene derivatives, topical compositions containing them, methods for their preparation, and intermediates therefor SYNTEX (U.S.A.) INC. (US) 1984-05-02 EP disclosed
US-4419368-A 2,2,3,3-TETRAHYDROXY- SYNTEX (U.S.A.) INC. (US) 1983-12-06 US disclosed
US-4229478-A Naphthaquinone anti-psoriatic agents SYNTEX (U.S.A.) INC. (US) 1980-10-21 US disclosed