Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | RHEB | Q15382 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7668913 | 0.86 | CYP3A4 (0.52) | CYP1A2CYP2C19CYP3A4CYP2C9RHEB | |
| SCHEMBL641111 | 0.85 | CYP2C9 (0.56) | CYP1A2CYP2C19CYP3A4CYP2C9RHEB | |
| Hydrochloric Acid SCHEMBL2884722 | 0.84 | CYP2C9 (0.54) | CYP1A2CYP2C19CYP3A4CYP2C9RHEB | |
| SCHEMBL30379539 | 0.82 | TSHR (0.54) | CYP1A2CYP2C19CYP3A4RHEBTSHR | |
| SCHEMBL9266509 | 0.82 | TSHR (0.54) | CYP1A2CYP2C19CYP3A4RHEBTSHR | |
| SCHEMBL9488215 | 0.82 | RHEB (0.55) | CYP1A2CYP2C19CYP3A4CYP2C9RHEB | |
| SCHEMBL1339155 | 0.81 | CYP3A4 (0.66) | CYP1A2CYP2C19CYP3A4CYP2C9RHEB | |
| SCHEMBL9629052 | 0.81 | GAA (0.47) | CYP1A2CYP2C19CYP3A4CYP2C9TSHR | |
| SCHEMBL3154096 | 0.81 | SLC6A4 (0.58) | CYP1A2CYP2C19CYP3A4CYP2C9MAPT | |
| SCHEMBL8107740 | 0.79 | CYP1A2 (0.53) | CYP1A2CYP2C19CYP3A4CYP2C9MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014199164-A1 | DIARYL SUBSTITUTED HETEROAROMATIC COMPOUNDS | AMPLA PHARMACEUTICALS, INC. (US) | 2014-12-18 | — | — | WO | disclosed |
| EP-0257011-B1 | PERMEATION MODIFIED ASYMMETRIC GAS SEPARATION MEMBRANES HAVING GRADED DENSITY SKINS | PERMEA, Inc. (US) | 1992-10-07 | — | — | EP | disclosed |
| US-4728346-A | PERMSELECTIVITY | PERMEA INC. (US) | 1988-03-01 | — | — | US | disclosed |
| EP-0257011-A2 | Permeation modified asymmetric gas separation membranes having graded density skins | PERMEA, Inc. (US) | 1988-02-24 | — | — | EP | disclosed |
| US-4575385-A | POLYSULFONES CONTACTED WITH BENZENE COMPOUND | MONSANTO COMPANY (US) | 1986-03-11 | — | — | US | disclosed |
| US-4166870-A | LAYER OF LATEX AND ACETYLENE GLACK VULCANIZED ON SHEET OF METAL | UNIGATE LIMITED (GB) | 1979-09-04 | — | — | US | disclosed |